FOSL1
Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| FOS like 1, AP-1 transcription factor subunit | MIM:136515 | Ensembl:ENSG00000175592 | HGNC:HGNC:13718 | PA28214 | 11q13.1 |
GO terms in FOSL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006935 | chemotaxis |
| BP | TAS | GO:0006968 | cellular defense response |
| BP | IEA | GO:0007296 | vitellogenesis |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | IEA | GO:0007612 | learning |
| BP | TAS | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | TAS | GO:0009615 | response to virus |
| BP | IEA | GO:0009629 | response to gravity |
| BP | IEA | GO:0031668 | cellular response to extracellular stimulus |
| BP | IEA | GO:0032570 | response to progesterone |
| BP | IEA | GO:0034097 | response to cytokine |
| BP | IEA | GO:0042542 | response to hydrogen peroxide |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0045787 | positive regulation of cell cycle |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0051412 | response to corticosterone |
| BP | IEA | GO:0051591 | response to cAMP |
| BP | IEA | GO:0060674 | placenta blood vessel development |
| BP | IDA | GO:0061614 | pri-miRNA transcription by RNA polymerase II |
| BP | IDA | GO:2000144 | positive regulation of DNA-templated transcription, initiation |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005829 | cytosol |
| CC | IEA | GO:0042734 | presynaptic membrane |
| CC | IEA | GO:0043005 | neuron projection |
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: FOSL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOSL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | ranklpathway | bone remodeling |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | tcrcalciumpathway | Calcium signaling in the CD4+ TCR pathway |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD199 | RG108 | 1 |
| iGMDRD463 | ZSTK 474 | 1 |
| iGMDRD1036 | X17AAG | 1 |
| iGMDRD573 | GSK-1904529A | 1 |
| iGMDRD455 | Idelalisib | 1 |
| iGMDRD561 | ABT-263 | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD264 | Bryostatin 1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOSL1
CLASSFICATION
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