IL1R2


Summary: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
interleukin 1 receptor type 2MIM:147811Ensembl:ENSG00000115590HGNC:HGNC:5994PA298102q11.2

Gene Categories:

DRUGGABLE GENOME

GO terms in IL1R2


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006955immune response
BPIEAGO:0010955negative regulation of protein processing
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0050712negative regulation of interleukin-1 alpha secretion
BPTASGO:0070498interleukin-1-mediated signaling pathway
BPIEAGO:1900016negative regulation of cytokine production involved in inflammatory response
BPIEAGO:2000660negative regulation of interleukin-1-mediated signaling pathway
CCIEAGO:0005576extracellular region
CCIEAGO:0005737cytoplasm
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
MFTASGO:0004908interleukin-1 receptor activity
MFIEAGO:0004910interleukin-1, type II, blocking receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0019966interleukin-1 binding

Gene expression in normal tissue: IL1R2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL1R2


DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6783783Interleukin-10 signaling
reactomeR-HSA-9020702Interleukin-1 signaling
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP4063Interleukin-10 signaling
pidil1pathwayIL1-mediated signaling events
netpathPathway_IL1IL1
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD322FK 8663
iGMDRD147Prima-13
iGMDRD6AM-5802
iGMDRD398Sepantronium3
iGMDRD237ABT-7513
iGMDRD67PENFLURIDOL3
iGMDRD341Triacsin c2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL1R2

​​​​