IL1R2
Summary: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 1 receptor type 2 | MIM:147811 | Ensembl:ENSG00000115590 | HGNC:HGNC:5994 | PA29810 | 2q11.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IL1R2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006955 | immune response |
| BP | IEA | GO:0010955 | negative regulation of protein processing |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0050712 | negative regulation of interleukin-1 alpha secretion |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IEA | GO:1900016 | negative regulation of cytokine production involved in inflammatory response |
| BP | IEA | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| MF | TAS | GO:0004908 | interleukin-1 receptor activity |
| MF | IEA | GO:0004910 | interleukin-1, type II, blocking receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0019966 | interleukin-1 binding |
Gene expression in normal tissue: IL1R2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL1R2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP4063 | Interleukin-10 signaling |
| pid | il1pathway | IL1-mediated signaling events |
| netpath | Pathway_IL1 | IL1 |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD322 | FK 866 | 3 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD341 | Triacsin c | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL1R2
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