IL2RA
Summary: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 2 receptor subunit alpha | MIM:147730 | Ensembl:ENSG00000134460 | HGNC:HGNC:6008 | PA29828 | 10p15.1 |
GO terms in IL2RA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0002437 | inflammatory response to antigenic stimulus |
| BP | IMP | GO:0002664 | regulation of T cell tolerance induction |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IEA | GO:0006924 | activation-induced cell death of T cells |
| BP | IBA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0006955 | immune response |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | IEA | GO:0007219 | Notch signaling pathway |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0038110 | interleukin-2-mediated signaling pathway |
| BP | IEA | GO:0042104 | positive regulation of activated T cell proliferation |
| BP | IEA | GO:0042130 | negative regulation of T cell proliferation |
| BP | IEA | GO:0045582 | positive regulation of T cell differentiation |
| BP | TAS | GO:0045589 | regulation of regulatory T cell differentiation |
| BP | IEA | GO:0046013 | regulation of T cell homeostatic proliferation |
| BP | IEA | GO:0050687 | negative regulation of defense response to virus |
| BP | IEA | GO:0050728 | negative regulation of inflammatory response |
| BP | IEA | GO:0050777 | negative regulation of immune response |
| CC | IEA | GO:0005622 | intracellular |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| MF | IBA | GO:0004911 | interleukin-2 receptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008144 | drug binding |
| MF | IBA | GO:0019976 | interleukin-2 binding |
Gene expression in normal tissue: IL2RA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL2RA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | il2pathway | il 2 signaling pathway |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-9020558 | Interleukin-2 signaling |
| reactome | R-HSA-912526 | Interleukin receptor SHC signaling |
| wikipathways | WP205 | IL-7 Signaling Pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4079 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP453 | Inflammatory Response Pathway |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il12_stat4pathway | IL12 signaling mediated by STAT4 |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcrcalciumpathway | Calcium signaling in the CD4+ TCR pathway |
| netpath | Pathway_IL2 | IL2 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD42 | Vorinostat | 4 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD77 | Itraconazole | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL2RA
CLASSFICATION
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