MAPK13


Summary: This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase 13MIM:602899Ensembl:ENSG00000156711HGNC:HGNC:6875PA306206p21.31

GO terms in MAPK13


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIDAGO:0006970response to osmotic stress
BPIEAGO:0007049cell cycle
BPIBAGO:0010468regulation of gene expression
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIMPGO:0032755positive regulation of interleukin-6 production
BPIDAGO:0034644cellular response to UV
BPIBAGO:0035556intracellular signal transduction
BPICGO:0050729positive regulation of inflammatory response
BPIDAGO:0051403stress-activated MAPK cascade
BPIDAGO:0070301cellular response to hydrogen peroxide
BPIBAGO:0071310cellular response to organic substance
BPIDAGO:0071347cellular response to interleukin-1
BPIDAGO:0072709cellular response to sorbitol
BPIDAGO:0072740cellular response to anisomycin
BPIDAGO:1903936cellular response to sodium arsenite
CCIBAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
MFIDAGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004707MAP kinase activity
MFIDAGO:0004707MAP kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding

Gene expression in normal tissue: MAPK13

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAPK13


DatabasePathway IDPathway Des.
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP2371Parkinsons Disease Pathway
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3612Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3941Oxidative Damage
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP481Insulin Signaling
wikipathwaysWP75Toll-like Receptor Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05133Pertussis - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
pidp38gammadeltapathwaySignaling mediated by p38-gamma and p38-delta
pharmgkbPA2032VEGF Signaling Pathway
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamapkpathwaymapkinase signaling pathway
biocartastathminpathwaystathmin and breast cancer resistance to antimicrotubule agents
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-171007p38MAPK events
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-373752Netrin-1 signaling
reactomeR-HSA-376172DSCAM interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD121GMX17783
iGMDRD512nutlin 36
iGMDRD289Parthenolide1
iGMDRD546BMS-7548073
iGMDRD945ML2145
iGMDRD781Sirolimus3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAPK13

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