RALA
Summary: The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAS like proto-oncogene A | MIM:179550 | Ensembl:ENSG00000006451 | HGNC:HGNC:9839 | PA34197 | 7p14.1 |
Gene Categories:
CELL SURFACEGO terms in RALA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005525 | GTP binding |
| MF | IPI | GO:0017022 | myosin binding |
| MF | IDA | GO:0019003 | GDP binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0031755 | Edg-2 lysophosphatidic acid receptor binding |
| MF | IPI | GO:0051117 | ATPase binding |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0030139 | endocytic vesicle |
| CC | TAS | GO:0030659 | cytoplasmic vesicle membrane |
| CC | IDA | GO:0032154 | cleavage furrow |
| CC | IEA | GO:0043209 | myelin sheath |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IEA | GO:0090543 | Flemming body |
| BP | IEA | GO:0001843 | neural tube closure |
| BP | IEA | GO:0006887 | exocytosis |
| BP | TAS | GO:0006935 | chemotaxis |
| BP | IEA | GO:0007049 | cell cycle |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007265 | Ras protein signal transduction |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0017157 | regulation of exocytosis |
| BP | IDA | GO:0031532 | actin cytoskeleton reorganization |
| BP | TAS | GO:0035722 | interleukin-12-mediated signaling pathway |
| BP | IEA | GO:0051301 | cell division |
| BP | IDA | GO:0051491 | positive regulation of filopodium assembly |
| BP | IDA | GO:0051665 | membrane raft localization |
| BP | TAS | GO:0061024 | membrane organization |
Gene expression in normal tissue: RALA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RALA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | foxopathway | FoxO family signaling |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| wikipathways | WP2290 | RalA downstream regulated genes |
| wikipathways | WP4100 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| reactome | R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-171007 | p38MAPK events |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
| biocarta | raspathway | ras signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD511 | CHEMBL399379 | 1 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RALA
CLASSFICATION
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