SRSF1
Summary: This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serine and arginine rich splicing factor 1 | MIM:600812 | Ensembl:ENSG00000136450 | HGNC:HGNC:10780 | PA35696 | 17q22 |
GO terms in SRSF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0003723 | RNA binding |
| MF | IDA | GO:0003729 | mRNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0043422 | protein kinase B binding |
| MF | IPI | GO:0044547 | DNA topoisomerase binding |
| MF | IEA | GO:0050733 | RS domain binding |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0035145 | exon-exon junction complex |
| CC | IDA | GO:0071013 | catalytic step 2 spliceosome |
| BP | IDA | GO:0000380 | alternative mRNA splicing, via spliceosome |
| BP | IBA | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| BP | IDA | GO:0000395 | mRNA 5'-splice site recognition |
| BP | IC | GO:0000398 | mRNA splicing, via spliceosome |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | TAS | GO:0006376 | mRNA splice site selection |
| BP | TAS | GO:0006397 | mRNA processing |
| BP | TAS | GO:0006405 | RNA export from nucleus |
| BP | TAS | GO:0006406 | mRNA export from nucleus |
| BP | TAS | GO:0031124 | mRNA 3'-end processing |
| BP | IEA | GO:0033120 | positive regulation of RNA splicing |
| BP | IBA | GO:0045292 | mRNA cis splicing, via spliceosome |
| BP | IEA | GO:0048709 | oligodendrocyte differentiation |
| BP | IEA | GO:0060048 | cardiac muscle contraction |
| BP | IEA | GO:0097421 | liver regeneration |
Gene expression in normal tissue: SRSF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SRSF1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109688 | Cleavage of Growing Transcript in the Termination Region |
| reactome | R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72165 | mRNA Splicing - Minor Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72187 | mRNA 3'-end processing |
| reactome | R-HSA-72202 | Transport of Mature Transcript to Cytoplasm |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-73856 | RNA Polymerase II Transcription Termination |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| wikipathways | WP411 | mRNA Processing |
| kegg | hsa03040 | Spliceosome - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD706 | BRD-K13999467 | 1 |
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD358 | Semagacestat | 1 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD45 | Thalidomide | 1 |
| iGMDRD946 | ML320 | 1 |
| iGMDRD394 | BX-795 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SRSF1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.