TCL1A


Summary: Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
T cell leukemia/lymphoma 1AMIM:186960Ensembl:ENSG00000100721HGNC:HGNC:11648PA3640014q32.13

GO terms in TCL1A


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIPIGO:0019901protein kinase binding
MFIDAGO:0042802identical protein binding
MFIPIGO:0042802identical protein binding
MFIMPGO:0043539protein serine/threonine kinase activator activity
BPTASGO:0007275multicellular organism development
BPIDAGO:0008284positive regulation of cell proliferation
BPIDAGO:0010918positive regulation of mitochondrial membrane potential
BPIDAGO:0032461positive regulation of protein oligomerization
BPIMPGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIDAGO:0043066negative regulation of apoptotic process
BPIDAGO:0070207protein homotrimerization
BPIDAGO:0071356cellular response to tumor necrosis factor
BPIDAGO:0071902positive regulation of protein serine/threonine kinase activity
CCIEAGO:0005634nucleus
CCIEAGO:0005783endoplasmic reticulum
CCIMPGO:0032991protein-containing complex

Gene expression in normal tissue: TCL1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TCL1A


DatabasePathway IDPathway Des.
netpathPathway_BCRBCR
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD126Tipifarnib3
iGMDRD887Compound 23 citrate2
iGMDRD512nutlin 33
iGMDRD398Sepantronium3
iGMDRD772BRD47703
iGMDRD147Prima-11

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TCL1A

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