THRSP


Summary: The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
thyroid hormone responsiveMIM:601926Ensembl:ENSG00000151365HGNC:HGNC:11800PA3650911q14.1

GO terms in THRSP


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006629lipid metabolic process
BPTASGO:0006853carnitine shuttle
BPIEAGO:0010866regulation of triglyceride biosynthetic process
BPISSGO:0046890regulation of lipid biosynthetic process
CCIDAGO:0005654nucleoplasm
CCISSGO:0005829cytosol
CCTASGO:0005829cytosol
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0042803protein homodimerization activity

Gene expression in normal tissue: THRSP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in THRSP


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-200425Import of palmitoyl-CoA into the mitochondrial matrix
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-8978868Fatty acid metabolism

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD255SB2250023
iGMDRD318PAC-11
iGMDRD945ML2146
iGMDRD289Parthenolide1
iGMDRD105Triptolide1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in THRSP

​​​​