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iGMDRD327

Canonical SMILES: CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO

InChI: InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+

InChI Key: FPOHNWQLNRZRFC-ZHACJKMWSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
LBH-589	CHEMBL483254	6918840	DB06603	Alone	Small Molecule

Drug Class:

Amines Antineoplastic Agents Antineoplastic and Immunomodulating Agents Carboxylic Acids Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate)Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 2-Ring Histone Deacetylase Inhibitors Hydroxy Acids Hydroxylamines Immunosuppressive Agents Moderate Risk QTc-Prolonging Agents P-glycoprotein/ABCB1 Substrates QTc Prolonging Agents

Drug Targets:

HDAC1 (Q13547)HDAC2 HDAC3 HDAC6 HDAC8

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
5159	PDGFRB	1
25937	WWTR1	1
3791	KDR	1
1956	EGFR	1
673	BRAF	1
9223	MAGI1	1

Gene in drug-gene network: Network Plot

Models in LBH-589

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