ANAPC5
Summary: This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| anaphase promoting complex subunit 5 | MIM:606948 | Ensembl:ENSG00000089053 | HGNC:HGNC:15713 | PA24788 | 12q24.31 |
Gene Categories:
TUMOR SUPPRESSORGO terms in ANAPC5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005680 | anaphase-promoting complex |
| CC | IDA | GO:0005680 | anaphase-promoting complex |
| CC | TAS | GO:0005829 | cytosol |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IBA | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| BP | TAS | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| BP | IBA | GO:0045842 | positive regulation of mitotic metaphase/anaphase transition |
| BP | IEA | GO:0051301 | cell division |
| BP | IBA | GO:0070979 | protein K11-linked ubiquitination |
| BP | IDA | GO:0070979 | protein K11-linked ubiquitination |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
Gene expression in normal tissue: ANAPC5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ANAPC5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| reactome | R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B |
| reactome | R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin |
| reactome | R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| reactome | R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| reactome | R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| reactome | R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase |
| reactome | R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-176412 | Phosphorylation of the APC/C |
| reactome | R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A |
| reactome | R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 |
| reactome | R-HSA-69052 | Switching of origins to a post-replicative state |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD231 | Importazole | 6 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD85 | Ursolic acid | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ANAPC5
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