BCL2A1


Summary: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
BCL2 related protein A1MIM:601056Ensembl:ENSG00000140379HGNC:HGNC:991PA2530315q25.1

GO terms in BCL2A1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIBAGO:0042803protein homodimerization activity
MFIBAGO:0046982protein heterodimerization activity
BPIBAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIBAGO:0043066negative regulation of apoptotic process
BPISSGO:0043066negative regulation of apoptotic process
BPIEAGO:0055085transmembrane transport
BPIBAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIBAGO:2001243negative regulation of intrinsic apoptotic signaling pathway
CCIBAGO:0005741mitochondrial outer membrane

Gene expression in normal tissue: BCL2A1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCL2A1


DatabasePathway IDPathway Des.
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3872Regulation of Apoptosis by Parathyroid Hormone-related Protein
pidbcr_5pathwayBCR signaling pathway
pidp53downstreampathwayDirect p53 effectors
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011
iGMDRD634SCHEMBL26080413
iGMDRD658CHEMBL16730391
iGMDRD446LY 21832403
iGMDRD506Fedratinib1
iGMDRD150RITA1
iGMDRD434BMS-5369246
iGMDRD33Entinostat2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL2A1

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