EPPK1
Summary: The protein encoded by this gene belongs to the plakin family of proteins, which play a role in the organization of cytoskeletal architecture. This family member is composed of several highly homologous plakin repeats. It may function to maintain the integrity of keratin intermediate filament networks in epithelial cells. Studies of the orthologous mouse protein suggest that it accelerates keratinocyte migration during wound healing. [provided by RefSeq, Oct 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| epiplakin 1 | MIM:607553 | Ensembl:ENSG00000261150 | HGNC:HGNC:15577 | PA27835 | 8q24.3 |
GO terms in EPPK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0005198 | structural molecule activity |
| MF | IEA | GO:0008092 | cytoskeletal protein binding |
| MF | IPI | GO:0019215 | intermediate filament binding |
| MF | IBA | GO:0045296 | cadherin binding |
| MF | IBA | GO:1990254 | keratin filament binding |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0005882 | intermediate filament |
| CC | IDA | GO:0005923 | bicellular tight junction |
| CC | IBA | GO:0016020 | membrane |
| CC | IEA | GO:0016323 | basolateral plasma membrane |
| CC | IEA | GO:0016327 | apicolateral plasma membrane |
| CC | IBA | GO:0030054 | cell junction |
| CC | IDA | GO:0030056 | hemidesmosome |
| CC | IEA | GO:0042995 | cell projection |
| CC | IBA | GO:0045095 | keratin filament |
| CC | IDA | GO:0045095 | keratin filament |
| CC | ISS | GO:0045095 | keratin filament |
| CC | IDA | GO:0071944 | cell periphery |
| CC | IDA | GO:0097356 | perinucleolar compartment |
| BP | ISS | GO:0010839 | negative regulation of keratinocyte proliferation |
| BP | IMP | GO:0030336 | negative regulation of cell migration |
| BP | IBA | GO:0042060 | wound healing |
| BP | IMP | GO:0042060 | wound healing |
| BP | IBA | GO:0045104 | intermediate filament cytoskeleton organization |
| BP | IDA | GO:0045109 | intermediate filament organization |
| BP | IMP | GO:0045109 | intermediate filament organization |
| BP | ISS | GO:0045109 | intermediate filament organization |
| BP | IBA | GO:0045110 | intermediate filament bundle assembly |
| BP | IMP | GO:0050680 | negative regulation of epithelial cell proliferation |
| BP | ISS | GO:0051548 | negative regulation of keratinocyte migration |
| BP | IMP | GO:0061045 | negative regulation of wound healing |
| BP | ISS | GO:1905041 | regulation of epithelium regeneration |
Gene expression in normal tissue: EPPK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD202 | Curcumin | 1 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD574 | Ruxolitinib | 1 |
| iGMDRD323 | Leptomycin B | 1 |
| iGMDRD141 | NSC48300 | 1 |
| iGMDRD133 | Lapatinib | 1 |
| iGMDRD287 | Myricetin | 1 |
| iGMDRD66 | Doxorubicin | 2 |
| iGMDRD94 | Narciclasine | 1 |
| iGMDRD646 | PHA-793887 | 1 |
| iGMDRD235 | SNS-032 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPPK1
CLASSFICATION
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