HIPK4
Summary: This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| homeodomain interacting protein kinase 4 | MIM:611712 | Ensembl:ENSG00000160396 | HGNC:HGNC:19007 | PA134883524 | 19q13.2 |
GO terms in HIPK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005737 | cytoplasm |
| BP | IEA | GO:0016572 | histone phosphorylation |
| BP | IEA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IEA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:1901796 | regulation of signal transduction by p53 class mediator |
Gene expression in normal tissue: HIPK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HIPK4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD484 | Pluripotin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HIPK4
CLASSFICATION
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