IRAK1
Summary: This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 1 receptor associated kinase 1 | MIM:300283 | Ensembl:ENSG00000184216 | HGNC:HGNC:6112 | PA29912 | Xq28 |
GO terms in IRAK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IMP | GO:0001959 | regulation of cytokine-mediated signaling pathway |
| BP | IBA | GO:0002224 | toll-like receptor signaling pathway |
| BP | TAS | GO:0002224 | toll-like receptor signaling pathway |
| BP | TAS | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | NAS | GO:0007165 | signal transduction |
| BP | NAS | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| BP | IDA | GO:0007250 | activation of NF-kappaB-inducing kinase activity |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0016032 | viral process |
| BP | IBA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IMP | GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| BP | IMP | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0032481 | positive regulation of type I interferon production |
| BP | IMP | GO:0032496 | response to lipopolysaccharide |
| BP | IMP | GO:0034134 | toll-like receptor 2 signaling pathway |
| BP | IBA | GO:0034142 | toll-like receptor 4 signaling pathway |
| BP | TAS | GO:0034162 | toll-like receptor 9 signaling pathway |
| BP | IEA | GO:0034605 | cellular response to heat |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IBA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | NAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | NAS | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IBA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | TAS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0051259 | protein complex oligomerization |
| BP | IMP | GO:0060337 | type I interferon signaling pathway |
| BP | TAS | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway |
| BP | IBA | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IMP | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IMP | GO:0070555 | response to interleukin-1 |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005811 | lipid droplet |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0010008 | endosome membrane |
| CC | NAS | GO:0045323 | interleukin-1 receptor complex |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | NAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004704 | NF-kappaB-inducing kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | IEA | GO:0031072 | heat shock protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | NAS | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: IRAK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IRAK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| biocarta | tollpathway | toll-like receptor pathway |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-193639 | p75NTR signals via NF-kB |
| reactome | R-HSA-193639 | p75NTR signals via NF-kB |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-209543 | p75NTR recruits signalling complexes |
| reactome | R-HSA-209543 | p75NTR recruits signalling complexes |
| reactome | R-HSA-209560 | NF-kB is activated and signals survival |
| reactome | R-HSA-445989 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450302 | activated TAK1 mediates p38 MAPK activation |
| reactome | R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-937039 | IRAK1 recruits IKK complex |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP262 | EBV LMP1 signaling |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP2865 | IL1 and megakaryocytes in obesity |
| wikipathways | WP3298 | Melatonin metabolism and effects |
| wikipathways | WP3656 | Interleukin-1 Induced Activation of NF-kappa-B |
| wikipathways | WP3851 | TLR4 Signaling and Tolerance |
| wikipathways | WP3858 | Toll-like Receptor Signaling |
| wikipathways | WP3877 | Simplified Depiction of MYD88 Distinct Input-Output Pathway |
| wikipathways | WP3926 | ApoE and miR-146 in inflammation and atherosclerosis |
| wikipathways | WP4136 | Fibrin Complement Receptor 3 Signaling Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| netpath | Pathway_IL1 | IL1 |
| pid | il1pathway | IL1-mediated signaling events |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | toll_endogenous_pathway | Endogenous TLR signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD289 | Parthenolide | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IRAK1
CLASSFICATION
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