MAP3K11


Summary: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase kinase kinase 11MIM:600050Ensembl:ENSG00000173327HGNC:HGNC:6850PA3059411q13.1

GO terms in MAP3K11


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005813centrosome
CCIDAGO:0005813centrosome
CCIDAGO:0005874microtubule
CCHDAGO:0016020membrane
BPIBAGO:0000165MAPK cascade
BPIMPGO:0000187activation of MAPK activity
BPIDAGO:0006468protein phosphorylation
BPIBAGO:0007017microtubule-based process
BPIMPGO:0007017microtubule-based process
BPTASGO:0007254JNK cascade
BPIEAGO:0007256activation of JNKK activity
BPIBAGO:0007257activation of JUN kinase activity
BPIMPGO:0007257activation of JUN kinase activity
BPIEAGO:0008219cell death
BPIMPGO:0008283cell proliferation
BPIBAGO:0043065positive regulation of apoptotic process
BPIMPGO:0043507positive regulation of JUN kinase activity
BPIEAGO:0043525positive regulation of neuron apoptotic process
BPIMPGO:0046330positive regulation of JNK cascade
BPIDAGO:0046777protein autophosphorylation
MFTASGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004706JUN kinase kinase kinase activity
MFISSGO:0004706JUN kinase kinase kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0031434mitogen-activated protein kinase kinase binding
MFIPIGO:0031435mitogen-activated protein kinase kinase kinase binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0042803protein homodimerization activity
MFIEAGO:0048365Rac GTPase binding

Gene expression in normal tissue: MAP3K11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP3K11


DatabasePathway IDPathway Des.
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP38794-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP481Insulin Signaling
netpathPathway_TNFalphaTNFalpha
pidcdc42_pathwayCDC42 signaling events
pidifngpathwayIFN-gamma pathway
pidrac1_pathwayRAC1 signaling pathway
pidreelinpathwayReelin signaling pathway
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
biocartamapkpathwaymapkinase signaling pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673000RAF activation
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6802946Signaling by moderate kinase activity BRAF mutants
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAF
reactomeR-HSA-6802957Oncogenic MAPK signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD255SB2250025
iGMDRD705Nakiterpiosin2
iGMDRD506Fedratinib2
iGMDRD662JQ-12
iGMDRD329Merck603
iGMDRD237ABT-7513
iGMDRD446LY 21832402
iGMDRD280CYTOCHALASIN B1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K11

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