STAT1
Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| signal transducer and activator of transcription 1 | MIM:600555 | Ensembl:ENSG00000115415 | HGNC:HGNC:11362 | PA36183 | 2q32.2 |
GO terms in STAT1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0001937 | negative regulation of endothelial cell proliferation |
| BP | ISS | GO:0002053 | positive regulation of mesenchymal cell proliferation |
| BP | IGI | GO:0002230 | positive regulation of defense response to virus by host |
| BP | IMP | GO:0002230 | positive regulation of defense response to virus by host |
| BP | ISS | GO:0003340 | negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0007221 | positive regulation of transcription of Notch receptor target |
| BP | IDA | GO:0007259 | JAK-STAT cascade |
| BP | IEA | GO:0007584 | response to nutrient |
| BP | ISS | GO:0008015 | blood circulation |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | IDA | GO:0010742 | macrophage derived foam cell differentiation |
| BP | IEA | GO:0016032 | viral process |
| BP | IMP | GO:0016525 | negative regulation of angiogenesis |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IDA | GO:0032727 | positive regulation of interferon-alpha production |
| BP | IEA | GO:0032869 | cellular response to insulin stimulus |
| BP | IDA | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | ISS | GO:0034097 | response to cytokine |
| BP | IMP | GO:0035456 | response to interferon-beta |
| BP | IMP | GO:0035458 | cellular response to interferon-beta |
| BP | TAS | GO:0038114 | interleukin-21-mediated signaling pathway |
| BP | IEA | GO:0042542 | response to hydrogen peroxide |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IMP | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | ISS | GO:0043434 | response to peptide hormone |
| BP | IMP | GO:0043542 | endothelial cell migration |
| BP | IMP | GO:0045648 | positive regulation of erythrocyte differentiation |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IGI | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0046725 | negative regulation by virus of viral protein levels in host cell |
| BP | ISS | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | ISS | GO:0051591 | response to cAMP |
| BP | IDA | GO:0051607 | defense response to virus |
| BP | IEA | GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process |
| BP | IDA | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | IMP | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | ISS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | TAS | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway |
| BP | IDA | GO:0060337 | type I interferon signaling pathway |
| BP | ISS | GO:0060337 | type I interferon signaling pathway |
| BP | TAS | GO:0060337 | type I interferon signaling pathway |
| BP | IMP | GO:0061326 | renal tubule development |
| BP | TAS | GO:0070102 | interleukin-6-mediated signaling pathway |
| BP | TAS | GO:0070106 | interleukin-27-mediated signaling pathway |
| BP | TAS | GO:0070757 | interleukin-35-mediated signaling pathway |
| BP | IDA | GO:0071346 | cellular response to interferon-gamma |
| BP | IEA | GO:0071407 | cellular response to organic cyclic compound |
| BP | ISS | GO:0072136 | metanephric mesenchymal cell proliferation involved in metanephros development |
| BP | ISS | GO:0072162 | metanephric mesenchymal cell differentiation |
| BP | ISS | GO:0072308 | negative regulation of metanephric nephron tubule epithelial cell differentiation |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0030425 | dendrite |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding |
| MF | IDA | GO:0003690 | double-stranded DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005164 | tumor necrosis factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0031730 | CCR5 chemokine receptor binding |
| MF | IPI | GO:0035035 | histone acetyltransferase binding |
| MF | IPI | GO:0035257 | nuclear hormone receptor binding |
| MF | IPI | GO:0042393 | histone binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0044389 | ubiquitin-like protein ligase binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0051721 | protein phosphatase 2A binding |
| MF | IPI | GO:0070491 | repressing transcription factor binding |
| MF | IDA | GO:1990841 | promoter-specific chromatin binding |
Gene expression in normal tissue: STAT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STAT1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | ifnapathway | ifn alpha signaling pathway |
| biocarta | ifngpathway | ifn gamma signaling pathway |
| biocarta | il22bppathway | il22 soluble receptor signaling pathway |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | p38mapkpathway | p38 mapk signaling pathway |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | tpopathway | tpo signaling pathway |
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-877312 | Regulation of IFNG signaling |
| reactome | R-HSA-8854691 | Interleukin-20 family signaling |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8939902 | Regulation of RUNX2 expression and activity |
| reactome | R-HSA-8984722 | Interleukin-35 Signalling |
| reactome | R-HSA-8985947 | Interleukin-9 signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9020956 | Interleukin-27 signaling |
| reactome | R-HSA-9020958 | Interleukin-21 signaling |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-912694 | Regulation of IFNA signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-982772 | Growth hormone receptor signaling |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP205 | IL-7 Signaling Pathway |
| wikipathways | WP2113 | Type III interferon signaling |
| wikipathways | WP22 | IL-9 Signaling Pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2853 | Endoderm Differentiation |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4197 | The human immune response to tuberculosis |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP474 | Endochondral Ossification |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| wikipathways | WP581 | EPO Receptor Signaling |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_IL11 | IL11 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_TSLP | TSLP |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | epopathway | EPO signaling pathway |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | fgf_pathway | FGF signaling pathway |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | ifngpathway | IFN-gamma pathway |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il23pathway | IL23-mediated signaling events |
| pid | il27pathway | IL27-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pid | tnfpathway | TNF receptor signaling pathway |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD506 | Fedratinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STAT1
CLASSFICATION
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