TOX3
Summary: The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TOX high mobility group box family member 3 | MIM:611416 | Ensembl:ENSG00000103460 | HGNC:HGNC:11972 | PA162406752 | 16q12.1 |
GO terms in TOX3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IDA | GO:0042981 | regulation of apoptotic process |
| BP | IDA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| CC | IEA | GO:0005634 | nucleus |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0034056 | estrogen response element binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0051219 | phosphoprotein binding |
Gene expression in normal tissue: TOX3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TOX3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP2858 | Ectoderm Differentiation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 6 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TOX3
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.