BAZ2B
Summary: This gene belongs to the bromodomain gene family. Members of this gene family encode proteins that are integral components of chromatin remodeling complexes. The encoded protein showed strong preference for the activating H3K14Ac mark in a histone peptide screen, suggesting a potential role in transcriptional activation. This gene may be associated with susceptibility to sudden cardiac death (SCD). [provided by RefSeq, Aug 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
bromodomain adjacent to zinc finger domain 2B | MIM:605683 | Ensembl:ENSG00000226266 | HGNC:HGNC:963 | PA25273 | 2q24.2 |
GO terms in BAZ2B
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0003677 | DNA binding |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0046872 | metal ion binding |
BP | TAS | GO:0006338 | chromatin remodeling |
BP | IEA | GO:0006351 | transcription, DNA-templated |
BP | NAS | GO:0006357 | regulation of transcription by RNA polymerase II |
CC | IEA | GO:0005634 | nucleus |
Gene expression in normal tissue: BAZ2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BAZ2B
Database | Pathway ID | Pathway Des. |
---|
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD126 | Tipifarnib | 1 |
iGMDRD467 | Motesanib | 1 |
iGMDRD434 | BMS-536924 | 1 |
iGMDRD532 | Olaparib | 1 |
iGMDRD283 | Bosutinib | 1 |
iGMDRD498 | GW441756X | 1 |
iGMDRD119 | Temsirolimus | 1 |
iGMDRD775 | NCGC00346967-01 | 1 |
iGMDRD190 | Nilotinib | 1 |
iGMDRD454 | JNK Inhibitor VIII | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BAZ2B