Summary: The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008].

CD40 ligandMIM:300386Ensembl:ENSG00000102245HGNC:HGNC:11935PA36626Xq26.3

GO terms in CD40LG

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006954inflammatory response
BPNASGO:0007159leukocyte cell-cell adhesion
BPIDAGO:0007257activation of JUN kinase activity
BPIEAGO:0010469regulation of signaling receptor activity
BPIDAGO:0030168platelet activation
BPIEAGO:0030183B cell differentiation
BPTASGO:0031295T cell costimulation
BPIDAGO:0032733positive regulation of interleukin-10 production
BPIDAGO:0032735positive regulation of interleukin-12 production
BPIDAGO:0032753positive regulation of interleukin-4 production
BPTASGO:0033209tumor necrosis factor-mediated signaling pathway
BPIDAGO:0042100B cell proliferation
BPIDAGO:0042102positive regulation of T cell proliferation
BPIDAGO:0043066negative regulation of apoptotic process
BPISSGO:0045190isotype switching
BPIEAGO:0048305immunoglobulin secretion
BPTASGO:0050776regulation of immune response
BPIEAGO:0051023regulation of immunoglobulin secretion
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIDAGO:2000353positive regulation of endothelial cell apoptotic process
CCIEAGO:0005615extracellular space
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0009897external side of plasma membrane
CCIDAGO:0009986cell surface
CCNASGO:0016021integral component of membrane
MFIEAGO:0005125cytokine activity
MFIEAGO:0005164tumor necrosis factor receptor binding
MFIPIGO:0005174CD40 receptor binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: CD40LG

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CD40LG

DatabasePathway IDPathway Des.
pidcd40_pathwayCD40/CD40L signaling
pidil4_2pathwayIL4-mediated signaling events
pidintegrin2_pathwayBeta2 integrin cell surface interactions
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
pidtcrcalciumpathwayCalcium signaling in the CD4+ TCR pathway
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04672Intestinal immune network for IgA production - Homo sapiens (human)
kegghsa05144Malaria - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05310Asthma - Homo sapiens (human)
kegghsa05320Autoimmune thyroid disease - Homo sapiens (human)
kegghsa05322Systemic lupus erythematosus - Homo sapiens (human)
kegghsa05330Allograft rejection - Homo sapiens (human)
kegghsa05340Primary immunodeficiency - Homo sapiens (human)
kegghsa05416Viral myocarditis - Homo sapiens (human)
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP453Inflammatory Response Pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
biocartacd40pathwaycd40l signaling pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD441TW 373
iGMDRD271Brefeldin A3
iGMDRD297Austocystin D3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD40LG