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CD44

Summary: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
CD44 molecule (Indian blood group)	MIM:107269	Ensembl:ENSG00000026508	HGNC:HGNC:1681	PA26221	11p13

Gene Categories:

CELL SURFACE PROTEASE DRUGGABLE GENOME

GO terms in CD44

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004888	transmembrane signaling receptor activity
MF	IBA	GO:0004896	cytokine receptor activity
MF	IDA	GO:0004896	cytokine receptor activity
MF	IPI	GO:0005515	protein binding
MF	NAS	GO:0005518	collagen binding
MF	IBA	GO:0005540	hyaluronic acid binding
MF	IDA	GO:0005540	hyaluronic acid binding
MF	NAS	GO:0005540	hyaluronic acid binding
BP	IBA	GO:0006954	inflammatory response
BP	IBA	GO:0007155	cell adhesion
BP	NAS	GO:0007160	cell-matrix adhesion
BP	IBA	GO:0007166	cell surface receptor signaling pathway
BP	TAS	GO:0022617	extracellular matrix disassembly
BP	TAS	GO:0030198	extracellular matrix organization
BP	IDA	GO:0030214	hyaluronan catabolic process
BP	TAS	GO:0030214	hyaluronan catabolic process
BP	IDA	GO:0033138	positive regulation of peptidyl-serine phosphorylation
BP	IMP	GO:0034116	positive regulation of heterotypic cell-cell adhesion
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	IMP	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BP	TAS	GO:0043312	neutrophil degranulation
BP	IDA	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
BP	IMP	GO:0044319	wound healing, spreading of cells
BP	IDA	GO:0044344	cellular response to fibroblast growth factor stimulus
BP	IDA	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
BP	TAS	GO:0050900	leukocyte migration
BP	IEP	GO:0051216	cartilage development
BP	TAS	GO:0060333	interferon-gamma-mediated signaling pathway
BP	IBA	GO:0070374	positive regulation of ERK1 and ERK2 cascade
BP	IDA	GO:0070374	positive regulation of ERK1 and ERK2 cascade
BP	IMP	GO:0070487	monocyte aggregation
BP	NAS	GO:0098609	cell-cell adhesion
BP	IMP	GO:1900625	positive regulation of monocyte aggregation
BP	IDA	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BP	IMP	GO:2000392	regulation of lamellipodium morphogenesis
CC	IDA	GO:0005794	Golgi apparatus
CC	IDA	GO:0005829	cytosol
CC	IBA	GO:0005886	plasma membrane
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	NAS	GO:0005887	integral component of plasma membrane
CC	ISS	GO:0005902	microvillus
CC	HDA	GO:0005925	focal adhesion
CC	IDA	GO:0009986	cell surface
CC	IBA	GO:0016323	basolateral plasma membrane
CC	IDA	GO:0016324	apical plasma membrane
CC	TAS	GO:0030667	secretory granule membrane
CC	IDA	GO:0031258	lamellipodium membrane
CC	IBA	GO:0035692	macrophage migration inhibitory factor receptor complex
CC	IDA	GO:0035692	macrophage migration inhibitory factor receptor complex
CC	IDA	GO:0042995	cell projection
CC	HDA	GO:0070062	extracellular exosome

Gene expression in normal tissue: CD44

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CD44

Database	Pathway ID	Pathway Des.
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1474228	Degradation of the extracellular matrix
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1630316	Glycosaminoglycan metabolism
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-202733	Cell surface interactions at the vascular wall
reactome	R-HSA-2142845	Hyaluronan metabolism
reactome	R-HSA-216083	Integrin cell surface interactions
reactome	R-HSA-2160916	Hyaluronan uptake and degradation
reactome	R-HSA-6798695	Neutrophil degranulation
reactome	R-HSA-71387	Metabolism of carbohydrates
reactome	R-HSA-877300	Interferon gamma signaling
reactome	R-HSA-913531	Interferon Signaling
pid	avb3_opn_pathway	Osteopontin-mediated events
kegg	hsa04512	ECM-receptor interaction - Homo sapiens (human)
kegg	hsa04640	Hematopoietic cell lineage - Homo sapiens (human)
kegg	hsa05131	Shigellosis - Homo sapiens (human)
kegg	hsa05169	Epstein-Barr virus infection - Homo sapiens (human)
kegg	hsa05205	Proteoglycans in cancer - Homo sapiens (human)
kegg	hsa05206	MicroRNAs in cancer - Homo sapiens (human)
netpath	Pathway_TGF_beta_Receptor	TGF_beta_Receptor
wikipathways	WP3646	Hepatitis C and Hepatocellular Carcinoma
wikipathways	WP399	Wnt Signaling Pathway and Pluripotency
wikipathways	WP615	Senescence and Autophagy in Cancer

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD634	SCHEMBL2608041	4
iGMDRD353	PD0325901	2
iGMDRD945	ML214	4
iGMDRD297	Austocystin D	1
iGMDRD889	Compound 7d-cis	1
iGMDRD148	Pifithrin-mu	3
iGMDRD1000	RG7356	1
iGMDRD318	PAC-1	1
iGMDRD523	Cyanoquinoline, 11	2
iGMDRD289	Parthenolide	1
iGMDRD116	CD437	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD44

SITE

DATATYPES

CLASSFICATION

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