CD44
Summary: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
CD44 molecule (Indian blood group) | MIM:107269 | Ensembl:ENSG00000026508 | HGNC:HGNC:1681 | PA26221 | 11p13 |
GO terms in CD44
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
MF | IBA | GO:0004896 | cytokine receptor activity |
MF | IDA | GO:0004896 | cytokine receptor activity |
MF | IPI | GO:0005515 | protein binding |
MF | NAS | GO:0005518 | collagen binding |
MF | IBA | GO:0005540 | hyaluronic acid binding |
MF | IDA | GO:0005540 | hyaluronic acid binding |
MF | NAS | GO:0005540 | hyaluronic acid binding |
BP | IBA | GO:0006954 | inflammatory response |
BP | IBA | GO:0007155 | cell adhesion |
BP | NAS | GO:0007160 | cell-matrix adhesion |
BP | IBA | GO:0007166 | cell surface receptor signaling pathway |
BP | TAS | GO:0022617 | extracellular matrix disassembly |
BP | TAS | GO:0030198 | extracellular matrix organization |
BP | IDA | GO:0030214 | hyaluronan catabolic process |
BP | TAS | GO:0030214 | hyaluronan catabolic process |
BP | IDA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
BP | IMP | GO:0034116 | positive regulation of heterotypic cell-cell adhesion |
BP | IMP | GO:0043066 | negative regulation of apoptotic process |
BP | IMP | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
BP | TAS | GO:0043312 | neutrophil degranulation |
BP | IDA | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
BP | IMP | GO:0044319 | wound healing, spreading of cells |
BP | IDA | GO:0044344 | cellular response to fibroblast growth factor stimulus |
BP | IDA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
BP | TAS | GO:0050900 | leukocyte migration |
BP | IEP | GO:0051216 | cartilage development |
BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
BP | IDA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
BP | IMP | GO:0070487 | monocyte aggregation |
BP | NAS | GO:0098609 | cell-cell adhesion |
BP | IMP | GO:1900625 | positive regulation of monocyte aggregation |
BP | IDA | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
BP | IMP | GO:2000392 | regulation of lamellipodium morphogenesis |
CC | IDA | GO:0005794 | Golgi apparatus |
CC | IDA | GO:0005829 | cytosol |
CC | IBA | GO:0005886 | plasma membrane |
CC | IDA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005886 | plasma membrane |
CC | NAS | GO:0005887 | integral component of plasma membrane |
CC | ISS | GO:0005902 | microvillus |
CC | HDA | GO:0005925 | focal adhesion |
CC | IDA | GO:0009986 | cell surface |
CC | IBA | GO:0016323 | basolateral plasma membrane |
CC | IDA | GO:0016324 | apical plasma membrane |
CC | TAS | GO:0030667 | secretory granule membrane |
CC | IDA | GO:0031258 | lamellipodium membrane |
CC | IBA | GO:0035692 | macrophage migration inhibitory factor receptor complex |
CC | IDA | GO:0035692 | macrophage migration inhibitory factor receptor complex |
CC | IDA | GO:0042995 | cell projection |
CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: CD44
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD44
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-109582 | Hemostasis |
reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
reactome | R-HSA-1474244 | Extracellular matrix organization |
reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
reactome | R-HSA-168249 | Innate Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
reactome | R-HSA-2142845 | Hyaluronan metabolism |
reactome | R-HSA-216083 | Integrin cell surface interactions |
reactome | R-HSA-2160916 | Hyaluronan uptake and degradation |
reactome | R-HSA-6798695 | Neutrophil degranulation |
reactome | R-HSA-71387 | Metabolism of carbohydrates |
reactome | R-HSA-877300 | Interferon gamma signaling |
reactome | R-HSA-913531 | Interferon Signaling |
pid | avb3_opn_pathway | Osteopontin-mediated events |
kegg | hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
wikipathways | WP615 | Senescence and Autophagy in Cancer |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD634 | SCHEMBL2608041 | 4 |
iGMDRD353 | PD0325901 | 2 |
iGMDRD945 | ML214 | 4 |
iGMDRD297 | Austocystin D | 1 |
iGMDRD889 | Compound 7d-cis | 1 |
iGMDRD148 | Pifithrin-mu | 3 |
iGMDRD1000 | RG7356 | 1 |
iGMDRD318 | PAC-1 | 1 |
iGMDRD523 | Cyanoquinoline, 11 | 2 |
iGMDRD289 | Parthenolide | 1 |
iGMDRD116 | CD437 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD44