PIM2
Summary: This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Pim-2 proto-oncogene, serine/threonine kinase | MIM:300295 | Ensembl:ENSG00000102096 | HGNC:HGNC:8987 | PA33319 | Xp11.23 |
GO terms in PIM2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| CC | IBA | GO:0005737 | cytoplasm |
| BP | IDA | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007140 | male meiotic nuclear division |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0008637 | apoptotic mitochondrial changes |
| BP | IEP | GO:0009615 | response to virus |
| BP | ISS | GO:0010508 | positive regulation of autophagy |
| BP | IEA | GO:0016239 | positive regulation of macroautophagy |
| BP | IEA | GO:0032091 | negative regulation of protein binding |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | ISS | GO:0050821 | protein stabilization |
Gene expression in normal tissue: PIM2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIM2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3640 | Imatinib and Chronic Myeloid Leukemia |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD121 | GMX1778 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIM2
CLASSFICATION
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