GUCY2C


Summary: This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive). [provided by RefSeq, Nov 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
guanylate cyclase 2CMIM:601330Ensembl:ENSG00000070019HGNC:HGNC:4688PA2906912p12.3

Gene Categories:

KINASEDRUGGABLE GENOME

GO terms in GUCY2C


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006182cGMP biosynthetic process
BPIEAGO:0006468protein phosphorylation
BPIBAGO:0007165signal transduction
BPTASGO:0007168receptor guanylyl cyclase signaling pathway
BPTASGO:0007586digestion
BPIBAGO:0009190cyclic nucleotide biosynthetic process
BPIEAGO:0009636response to toxic substance
BPIEAGO:0035556intracellular signal transduction
BPIEAGO:0042127regulation of cell proliferation
CCIEAGO:0005789endoplasmic reticulum membrane
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0008074guanylate cyclase complex, soluble
CCIEAGO:0016021integral component of membrane
MFIBAGO:0004016adenylate cyclase activity
MFIBAGO:0004383guanylate cyclase activity
MFIEAGO:0004672protein kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0005525GTP binding
MFIEAGO:0015643toxic substance binding

Gene expression in normal tissue: GUCY2C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GUCY2C


DatabasePathway IDPathway Des.
kegghsa00230Purine metabolism - Homo sapiens (human)
biocartano1pathwayactions of nitric oxide in the heart
reactomeR-HSA-1643685Disease
reactomeR-HSA-5339562Uptake and actions of bacterial toxins
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-8935690Digestion
reactomeR-HSA-8942233Intestinal infectious diseases
reactomeR-HSA-8963743Digestion and absorption

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD138PX 123
iGMDRD77Itraconazole3
iGMDRD434BMS-5369243
iGMDRD670ML 2103
iGMDRD639YK 4-2792
iGMDRD398Sepantronium4
iGMDRD71Sparfosic acid3
iGMDRD297Austocystin D3
iGMDRD211(1S,3R)-RSL33

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GUCY2C

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