STK26
Summary: The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serine/threonine kinase 26 | MIM:300547 | Ensembl:ENSG00000134602 | HGNC:HGNC:18174 | PA166123740 | Xq26.2 |
GO terms in STK26
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000185 | activation of MAPKKK activity |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IMP | GO:0009267 | cellular response to starvation |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IDA | GO:0030033 | microvillus assembly |
| BP | IMP | GO:0030336 | negative regulation of cell migration |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0042542 | response to hydrogen peroxide |
| BP | IDA | GO:0042981 | regulation of apoptotic process |
| BP | IMP | GO:0046777 | protein autophosphorylation |
| BP | IBA | GO:0048812 | neuron projection morphogenesis |
| BP | IMP | GO:1903205 | regulation of hydrogen peroxide-induced cell death |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005798 | Golgi-associated vesicle |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0012506 | vesicle membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0071944 | cell periphery |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IMP | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: STK26
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STK26
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-75153 | Apoptotic execution phase |
| pid | lkb1_pathway | LKB1 signaling events |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD889 | Compound 7d-cis | 6 |
| iGMDRD307 | Manumycin A | 6 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 6 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD690 | PRIMA-1MET | 6 |
| iGMDRD901 | ELCPK | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STK26
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