TRADD
Summary: The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNFRSF1A associated via death domain | MIM:603500 | Ensembl:ENSG00000102871 | HGNC:HGNC:12030 | PA36707 | 16q22.1 |
Gene Categories:
PROTEASEGO terms in TRADD
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0031264 | death-inducing signaling complex |
| CC | IDA | GO:0043235 | receptor complex |
| CC | IEA | GO:0045121 | membrane raft |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| BP | TAS | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0043065 | positive regulation of apoptotic process |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:0051291 | protein heterooligomerization |
| BP | IEA | GO:0051798 | positive regulation of hair follicle development |
| BP | TAS | GO:0071550 | death-inducing signaling complex assembly |
| BP | IMP | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | TAS | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | TAS | GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | TAS | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| MF | IEA | GO:0005164 | tumor necrosis factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019900 | kinase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | IPI | GO:0060090 | molecular adaptor activity |
| MF | IPI | GO:0070513 | death domain binding |
Gene expression in normal tissue: TRADD
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRADD
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-140534 | via Death Receptors in the presence of ligand |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-3371378 | Regulation by c-FLIP |
| reactome | R-HSA-5213460 | RIPK1-mediated regulated necrosis |
| reactome | R-HSA-5218859 | Regulated Necrosis |
| reactome | R-HSA-5218900 | CASP8 activity is inhibited |
| reactome | R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway |
| reactome | R-HSA-5357786 | TNFR1-induced proapoptotic signaling |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5357905 | Regulation of TNFR1 signaling |
| reactome | R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway |
| reactome | R-HSA-5675482 | Regulation of necroptotic cell death |
| reactome | R-HSA-69416 | Dimerization of procaspase-8 |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75893 | TNF signaling |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| biocarta | soddpathway | sodd/tnfr1 signaling pathway |
| biocarta | stresspathway | tnf/stress related signaling |
| biocarta | tnfr1pathway | tnfr1 signaling pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | tnfpathway | TNF receptor signaling pathway |
| pid | trail_pathway | TRAIL signaling pathway |
| netpath | Pathway_TNFalpha | TNFalpha |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2513 | Nanoparticle triggered regulated necrosis |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP262 | EBV LMP1 signaling |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD451 | Serdemetan | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRADD
CLASSFICATION
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