TWF2


Summary: The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
twinfilin actin binding protein 2MIM:607433Ensembl:ENSG00000247596HGNC:HGNC:9621PA1624074293p21.2

Gene Categories:

TYROSINE KINASEKINASE

GO terms in TWF2


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0010591regulation of lamellipodium assembly
BPIMPGO:0010592positive regulation of lamellipodium assembly
BPIBAGO:0010976positive regulation of neuron projection development
BPIMPGO:0010976positive regulation of neuron projection development
BPIEAGO:0030030cell projection organization
BPIBAGO:0030042actin filament depolymerization
BPISSGO:0030837negative regulation of actin filament polymerization
BPICGO:0032532regulation of microvillus length
BPIMPGO:0032956regulation of actin cytoskeleton organization
BPIBAGO:0042989sequestering of actin monomers
BPISSGO:0042989sequestering of actin monomers
BPIMPGO:0045773positive regulation of axon extension
BPIBAGO:0051016barbed-end actin filament capping
BPISSGO:0051016barbed-end actin filament capping
BPIMPGO:0071300cellular response to retinoic acid
BPIMPGO:0071363cellular response to growth factor stimulus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCNASGO:0005737cytoplasm
CCIEAGO:0005856cytoskeleton
CCIBAGO:0005884actin filament
CCIBAGO:0030016myofibril
CCISSGO:0030016myofibril
CCISSGO:0030027lamellipodium
CCISSGO:0030175filopodium
CCIDAGO:0030426growth cone
CCISSGO:0032420stereocilium
CCISSGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
MFHDAGO:0003723RNA binding
MFIBAGO:0003785actin monomer binding
MFISSGO:0003785actin monomer binding
MFIPIGO:0005080protein kinase C binding
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFISSGO:0005546phosphatidylinositol-4,5-bisphosphate binding
MFHDAGO:0045296cadherin binding
MFIBAGO:0051015actin filament binding

Gene expression in normal tissue: TWF2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TWF2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD505Pevonedistat3
iGMDRD399Selumetinib3
iGMDRD57Chloropentafluorobenzene3
iGMDRD780PP-303
iGMDRD782DC-45-A23
iGMDRD318PAC-16
iGMDRD226ML0063
iGMDRD781Sirolimus3
iGMDRD474Avrainvillamide3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TWF2

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