CAMKK2


Summary: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
calcium/calmodulin dependent protein kinase kinase 2MIM:615002Ensembl:ENSG00000110931HGNC:HGNC:1470PA2605212q24.31

GO terms in CAMKK2


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004713protein tyrosine kinase activity
MFIDAGO:0005509calcium ion binding
MFTASGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding
BPTASGO:0000165MAPK cascade
BPIMPGO:0001934positive regulation of protein phosphorylation
BPIDAGO:0006468protein phosphorylation
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPTASGO:0019722calcium-mediated signaling
BPTASGO:0034614cellular response to reactive oxygen species
BPTASGO:0045859regulation of protein kinase activity
BPTASGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0046777protein autophosphorylation
BPIMPGO:0061762CAMKK-AMPK signaling cascade
BPICGO:1903599positive regulation of autophagy of mitochondrion
CCIMPGO:0005622intracellular
CCTASGO:0005622intracellular
CCIDAGO:0005829cytosol
CCIEAGO:0042995cell projection

Gene expression in normal tissue: CAMKK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CAMKK2


DatabasePathway IDPathway Des.
biocartacacampathwayca-calmodulin-dependent protein kinase activation
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
biocartanfatpathwaynfat and hypertrophy of the heart
biocartapgc1apathwayregulation of pgc-1a
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
netpathPathway_GhrelinGhrelin
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD193Fqi11
iGMDRD123Isoevodiamine3
iGMDRD60Quinoclamine2
iGMDRD369TGX-1153
iGMDRD505Pevonedistat6
iGMDRD202Curcumin4
iGMDRD158NSC1415401
iGMDRD144NSC953972
iGMDRD150RITA3
iGMDRD560MK-22063
iGMDRD77Itraconazole3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CAMKK2

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