CDK10
Summary: The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase 10 | MIM:603464 | Ensembl:ENSG00000185324 | HGNC:HGNC:1770 | PA26307 | 16q24.3 |
GO terms in CDK10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0036064 | ciliary basal body |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007089 | traversing start control point of mitotic cell cycle |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IEA | GO:0030030 | cell projection organization |
| BP | IMP | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IEA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:1902018 | negative regulation of cilium assembly |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: CDK10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDK10
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD341 | Triacsin c | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDK10
CLASSFICATION
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