Summary: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008].

colony stimulating factor 2MIM:138960Ensembl:ENSG00000164400HGNC:HGNC:2434PA269375q31.1

GO terms in CSF2

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIDAGO:0043231intracellular membrane-bounded organelle
BPTASGO:0000165MAPK cascade
BPIEAGO:0001821histamine secretion
BPIEAGO:0001892embryonic placenta development
BPIBAGO:0002521leukocyte differentiation
BPIEAGO:0006955immune response
BPIDAGO:0008284positive regulation of cell proliferation
BPIEAGO:0010469regulation of signaling receptor activity
BPIDAGO:0010628positive regulation of gene expression
BPIDAGO:0010744positive regulation of macrophage derived foam cell differentiation
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0030223neutrophil differentiation
BPIEAGO:0030224monocyte differentiation
BPIDAGO:0032747positive regulation of interleukin-23 production
BPIEAGO:0034021response to silicon dioxide
BPIEAGO:0034405response to fluid shear stress
BPIEAGO:0042045epithelial fluid transport
BPIEAGO:0042116macrophage activation
BPIDAGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPIDAGO:0043011myeloid dendritic cell differentiation
BPIEAGO:0045187regulation of circadian sleep/wake cycle, sleep
BPTASGO:0045637regulation of myeloid cell differentiation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045918negative regulation of cytolysis
BPIEAGO:0071222cellular response to lipopolysaccharide
BPIDAGO:0071803positive regulation of podosome assembly
BPIDAGO:0097011cellular response to granulocyte macrophage colony-stimulating factor stimulus
BPIDAGO:0097028dendritic cell differentiation
BPIDAGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
MFTASGO:0004713protein tyrosine kinase activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIBAGO:0005125cytokine activity
MFIDAGO:0005125cytokine activity
MFIEAGO:0005129granulocyte macrophage colony-stimulating factor receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0008083growth factor activity

Gene expression in normal tissue: CSF2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CSF2

DatabasePathway IDPathway Des.
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
pidap1_pathwayAP-1 transcription factor network
pidgmcsf_pathwayGMCSF-mediated signaling events
pidintegrin_a9b1_pathwayAlpha9 beta1 integrin signaling events
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
pidrb_1pathwayRegulation of retinoblastoma protein
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidsyndecan_2_pathwaySyndecan-2-mediated signaling events
pidtcrcalciumpathwayCalcium signaling in the CD4+ TCR pathway
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
wikipathwaysWP2849Hematopoietic Stem Cell Differentiation
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3624Lung fibrosis
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP3892Development of pulmonary dendritic cells and macrophage subsets
wikipathwaysWP4063Interleukin-10 signaling
wikipathwaysWP4105Transcriptional regulation by RUNX1
wikipathwaysWP530Cytokines and Inflammatory Response
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6783783Interleukin-10 signaling
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939246RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
reactomeR-HSA-912526Interleukin receptor SHC signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD885Compound 1102
iGMDRD61Kinetin riboside2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CSF2