FLNA


Summary: The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
filamin AMIM:300017Ensembl:ENSG00000196924HGNC:HGNC:3754PA28172Xq28

GO terms in FLNA


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0001664G-protein coupled receptor binding
MFHDAGO:0003723RNA binding
MFIDAGO:0005515protein binding
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIDAGO:0015459potassium channel regulator activity
MFIDAGO:0017048Rho GTPase binding
MFIDAGO:0017160Ral GTPase binding
MFIPIGO:0019900kinase binding
MFIDAGO:0031267small GTPase binding
MFIEAGO:0031852mu-type opioid receptor binding
MFIDAGO:0034988Fc-gamma receptor I complex binding
MFIDAGO:0042803protein homodimerization activity
MFIPIGO:0044325ion channel binding
MFHDAGO:0045296cadherin binding
MFIEAGO:0046332SMAD binding
MFIDAGO:0048365Rac GTPase binding
MFIDAGO:0051015actin filament binding
MFIPIGO:0051020GTPase binding
BPTASGO:0002576platelet degranulation
BPIMPGO:0007195adenylate cyclase-inhibiting dopamine receptor signaling pathway
BPIDAGO:0016479negative regulation of transcription by RNA polymerase I
BPIEAGO:0021943formation of radial glial scaffolds
BPIEAGO:0021987cerebral cortex development
BPTASGO:0030168platelet activation
BPIDAGO:0030334regulation of cell migration
BPIDAGO:0031532actin cytoskeleton reorganization
BPIEAGO:0032233positive regulation of actin filament bundle assembly
BPTASGO:0034329cell junction assembly
BPIDAGO:0034394protein localization to cell surface
BPIMPGO:0042177negative regulation of protein catabolic process
BPIEAGO:0042789mRNA transcription by RNA polymerase II
BPIMPGO:0043066negative regulation of apoptotic process
BPIDAGO:0043113receptor clustering
BPHMPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0043433negative regulation of DNA-binding transcription factor activity
BPIDAGO:0044319wound healing, spreading of cells
BPIDAGO:0045184establishment of protein localization
BPIMPGO:0050821protein stabilization
BPIMPGO:0051220cytoplasmic sequestering of protein
BPIDAGO:0051764actin crosslink formation
BPIMPGO:0060271cilium assembly
BPHMPGO:0070527platelet aggregation
BPIGIGO:0071526semaphorin-plexin signaling pathway
BPIDAGO:0072659protein localization to plasma membrane
BPIDAGO:0090307mitotic spindle assembly
BPIEAGO:0097368establishment of Sertoli cell barrier
BPIMPGO:1900026positive regulation of substrate adhesion-dependent cell spreading
BPIDAGO:1901381positive regulation of potassium ion transmembrane transport
BPIEAGO:1902396protein localization to bicellular tight junction
BPICGO:1905000regulation of membrane repolarization during atrial cardiac muscle cell action potential
BPISSGO:1905031regulation of membrane repolarization during cardiac muscle cell action potential
BPIEAGO:2000179positive regulation of neural precursor cell proliferation
BPIMPGO:2001046positive regulation of integrin-mediated signaling pathway
BPIEAGO:2001224positive regulation of neuron migration
CCTASGO:0005576extracellular region
CCIDAGO:0005634nucleus
CCIMPGO:0005730nucleolus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIDAGO:0005911cell-cell junction
CCHDAGO:0005925focal adhesion
CCICGO:0015629actin cytoskeleton
CCIDAGO:0015629actin cytoskeleton
CCHDAGO:0016020membrane
CCISSGO:0030018Z disc
CCIEAGO:0030863cortical cytoskeleton
CCIDAGO:0031523Myb complex
CCIDAGO:0031941filamentous actin
CCIEAGO:0043025neuronal cell body
CCIEAGO:0043198dendritic shaft
CCIEAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
CCIEAGO:0097440apical dendrite

Gene expression in normal tissue: FLNA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FLNA


DatabasePathway IDPathway Des.
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2593JAK-STAT
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3668Hypothesized Pathways in Pathogenesis of Cardiovascular Disease
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP395IL-4 Signaling Pathway
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pidwnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_ProlactinProlactin
netpathPathway_TNFalphaTNFalpha
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-430116GP1b-IX-V activation signalling
reactomeR-HSA-446353Cell-extracellular matrix interactions
reactomeR-HSA-446728Cell junction organization
reactomeR-HSA-5627123RHO GTPases activate PAKs
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD64Parbendazole3
iGMDRD23Gossypol3
iGMDRD286Nsc 6328393
iGMDRD100Zebularine3
iGMDRD434BMS-5369243
iGMDRD192CIL561
iGMDRD171Pemetrexed3
iGMDRD870BRD636106
iGMDRD137Indisulam2
iGMDRD158NSC1415401
iGMDRD177Teniposide3
iGMDRD314Tanespimycin2
iGMDRD193Fqi11
iGMDRD670ML 2102
iGMDRD494Neopeltolide3
iGMDRD584VER 1550083
iGMDRD607Ubistatin B3
iGMDRD772BRD47703

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FLNA

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