IGFBP2
Summary: The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| insulin like growth factor binding protein 2 | MIM:146731 | Ensembl:ENSG00000115457 | HGNC:HGNC:5471 | PA29704 | 2q35 |
GO terms in IGFBP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0031994 | insulin-like growth factor I binding |
| MF | IDA | GO:0031994 | insulin-like growth factor I binding |
| MF | IBA | GO:0031995 | insulin-like growth factor II binding |
| MF | ISS | GO:0031995 | insulin-like growth factor II binding |
| CC | ISS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0001558 | regulation of cell growth |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0007584 | response to nutrient |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | IEA | GO:0010226 | response to lithium ion |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0032526 | response to retinoic acid |
| BP | IEA | GO:0032870 | cellular response to hormone stimulus |
| BP | IDA | GO:0042104 | positive regulation of activated T cell proliferation |
| BP | IEA | GO:0042493 | response to drug |
| BP | IBA | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway |
| BP | IC | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway |
| BP | ISS | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway |
| BP | IEA | GO:0043627 | response to estrogen |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0051384 | response to glucocorticoid |
| BP | TAS | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
Gene expression in normal tissue: IGFBP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IGFBP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP3391 | Senescence-Associated Secretory Phenotype (SASP) |
| wikipathways | WP3614 | Photodynamic therapy-induced HIF-1 survival signaling |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD358 | Semagacestat | 1 |
| iGMDRD142 | NSC74859 | 1 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD239 | Dasatinib | 2 |
| iGMDRD489 | GSK-461364 | 1 |
| iGMDRD15 | Tacedinaline | 1 |
| iGMDRD185 | DMOG | 1 |
| iGMDRD563 | AT-406 | 1 |
| iGMDRD640 | CAY10618 | 1 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD208 | Necrosulfonamide | 1 |
| iGMDRD479 | Veliparib | 1 |
| iGMDRD215 | CCT007093 | 1 |
| iGMDRD203 | STF-31 | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD415 | LE-135 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IGFBP2
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