Summary: This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015].

nuclear factor, erythroid 2 like 2MIM:600492Ensembl:ENSG00000116044HGNC:HGNC:7782PA315882q31.2

GO terms in NFE2L2

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005886plasma membrane
CCISSGO:0032993protein-DNA complex
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006366transcription by RNA polymerase II
BPIEAGO:0006954inflammatory response
BPIDAGO:0010499proteasomal ubiquitin-independent protein catabolic process
BPIGIGO:0010628positive regulation of gene expression
BPIEAGO:0010667negative regulation of cardiac muscle cell apoptotic process
BPIEAGO:0010976positive regulation of neuron projection development
BPIDAGO:0016567protein ubiquitination
BPIEAGO:0030194positive regulation of blood coagulation
BPISSGO:0030968endoplasmic reticulum unfolded protein response
BPIBAGO:0034599cellular response to oxidative stress
BPNASGO:0034599cellular response to oxidative stress
BPTASGO:0034599cellular response to oxidative stress
BPIMPGO:0036003positive regulation of transcription from RNA polymerase II promoter in response to stress
BPIEAGO:0036091positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
BPISSGO:0036499PERK-mediated unfolded protein response
BPTASGO:0036499PERK-mediated unfolded protein response
BPIEAGO:0042149cellular response to glucose starvation
BPIDAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPIEAGO:0043536positive regulation of blood vessel endothelial cell migration
BPIEAGO:0045454cell redox homeostasis
BPIEAGO:0045766positive regulation of angiogenesis
BPIBAGO:0045893positive regulation of transcription, DNA-templated
BPICGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0045995regulation of embryonic development
BPIEAGO:0046223aflatoxin catabolic process
BPIEAGO:0046326positive regulation of glucose import
BPIMPGO:0061419positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
BPIMPGO:0070301cellular response to hydrogen peroxide
BPIMPGO:0071356cellular response to tumor necrosis factor
BPIDAGO:0071498cellular response to fluid shear stress
BPIMPGO:0071499cellular response to laminar fluid shear stress
BPIEAGO:1902037negative regulation of hematopoietic stem cell differentiation
BPIMPGO:1902176negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
BPTASGO:1903071positive regulation of ER-associated ubiquitin-dependent protein catabolic process
BPIGIGO:1903206negative regulation of hydrogen peroxide-induced cell death
BPIEAGO:1903788positive regulation of glutathione biosynthetic process
BPIEAGO:1904385cellular response to angiotensin
BPIEAGO:1904753negative regulation of vascular associated smooth muscle cell migration
BPIEAGO:2000121regulation of removal of superoxide radicals
BPIMPGO:2000352negative regulation of endothelial cell apoptotic process
BPIEAGO:2000379positive regulation of reactive oxygen species metabolic process
MFIBAGO:0000976transcription regulatory region sequence-specific DNA binding
MFTASGO:0000976transcription regulatory region sequence-specific DNA binding
MFIEAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIPIGO:0001102RNA polymerase II activating transcription factor binding
MFIEAGO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
MFIEAGO:0001221transcription cofactor binding
MFIDAGO:0003677DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIPIGO:0019904protein domain specific binding
MFTASGO:0044212transcription regulatory region DNA binding

Gene expression in normal tissue: NFE2L2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NFE2L2

DatabasePathway IDPathway Des.
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
wikipathwaysWP2435Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis
wikipathwaysWP2586Aryl Hydrocarbon Receptor
wikipathwaysWP28Selenium Metabolism and Selenoproteins
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP3Transcriptional activation by NRF2
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3612Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
wikipathwaysWP3613Photodynamic therapy-induced unfolded protein response
wikipathwaysWP3624Lung fibrosis
wikipathwaysWP3670Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway
wikipathwaysWP408Oxidative Stress
wikipathwaysWP4206Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway
biocartaarenrf2pathwayoxidative stress induced gene expression via nrf2

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD746CDK9 Inhibitor1
iGMDRD372TGX 2211

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NFE2L2