RPL10


Summary: This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ribosomal protein L10MIM:312173Ensembl:ENSG00000147403HGNC:HGNC:10298PA34660Xq28

GO terms in RPL10


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005790smooth endoplasmic reticulum
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCHDAGO:0016020membrane
CCHDAGO:0022625cytosolic large ribosomal subunit
CCIBAGO:0022625cytosolic large ribosomal subunit
CCIDAGO:0022625cytosolic large ribosomal subunit
CCIDAGO:0032991protein-containing complex
BPIBAGO:0000027ribosomal large subunit assembly
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
BPICGO:0006412translation
BPNASGO:0006412translation
BPTASGO:0006413translational initiation
BPIMPGO:0006417regulation of translation
BPTASGO:0006614SRP-dependent cotranslational protein targeting to membrane
BPIMPGO:0043066negative regulation of apoptotic process
BPIMPGO:1990403embryonic brain development
MFHDAGO:0003723RNA binding
MFIBAGO:0003735structural constituent of ribosome
MFIDAGO:0003735structural constituent of ribosome
MFIMPGO:0003735structural constituent of ribosome
MFNASGO:0003735structural constituent of ribosome
MFIPIGO:0005515protein binding
MFIMPGO:0045182translation regulator activity

Gene expression in normal tissue: RPL10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RPL10


DatabasePathway IDPathway Des.
kegghsa03010Ribosome - Homo sapiens (human)
wikipathwaysWP477Cytoplasmic Ribosomal Proteins
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expression
reactomeR-HSA-156842Eukaryotic Translation Elongation
reactomeR-HSA-156902Peptide chain elongation
reactomeR-HSA-1643685Disease
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168255Influenza Life Cycle
reactomeR-HSA-168273Influenza Viral RNA Transcription and Replication
reactomeR-HSA-1799339SRP-dependent cotranslational protein targeting to membrane
reactomeR-HSA-1799339SRP-dependent cotranslational protein targeting to membrane
reactomeR-HSA-192823Viral mRNA Translation
reactomeR-HSA-2408522Selenoamino acid metabolism
reactomeR-HSA-2408557Selenocysteine synthesis
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosol
reactomeR-HSA-71291Metabolism of amino acids and derivatives
reactomeR-HSA-72312rRNA processing
reactomeR-HSA-72613Eukaryotic Translation Initiation
reactomeR-HSA-72689Formation of a pool of free 40S subunits
reactomeR-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunit
reactomeR-HSA-72737Cap-dependent Translation Initiation
reactomeR-HSA-72764Eukaryotic Translation Termination
reactomeR-HSA-72766Translation
reactomeR-HSA-72766Translation
reactomeR-HSA-8868773rRNA processing in the nucleus and cytosol
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
reactomeR-HSA-927802Nonsense-Mediated Decay (NMD)
reactomeR-HSA-975956Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
reactomeR-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD772BRD47703
iGMDRD512nutlin 33
iGMDRD424Tamatinib1
iGMDRD532Olaparib3
iGMDRD730Kahalalide F3
iGMDRD74Idarubicin3
iGMDRD341Triacsin c3
iGMDRD639YK 4-2793
iGMDRD444Tivantinib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPL10

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