TLX1
Summary: This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| T cell leukemia homeobox 1 | MIM:186770 | Ensembl:ENSG00000107807 | HGNC:HGNC:5056 | PA35095 | 10q24.31 |
GO terms in TLX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| CC | IEA | GO:0005634 | nucleus |
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: TLX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TLX1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| wikipathways | WP2023 | Cell Differentiation - Index expanded |
| wikipathways | WP2029 | Cell Differentiation - Index |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD133 | Lapatinib | 1 |
| iGMDRD2 | PK-11195 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD599 | Salermide | 6 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD267 | Oligomycin A | 6 |
| iGMDRD309 | 17AAG | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TLX1
CLASSFICATION
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