YBX1
Summary: This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Y-box binding protein 1 | MIM:154030 | Ensembl:ENSG00000065978 | HGNC:HGNC:8014 | PA31791 | 1p34.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in YBX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007219 | Notch signaling pathway |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0051154 | negative regulation of striated muscle cell differentiation |
| BP | IEA | GO:0051781 | positive regulation of cell division |
| BP | IMP | GO:0070934 | CRD-mediated mRNA stabilization |
| BP | IMP | GO:1903608 | protein localization to cytoplasmic stress granule |
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005689 | U12-type spliceosomal complex |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0010494 | cytoplasmic stress granule |
| CC | IDA | GO:0031965 | nuclear membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070937 | CRD-mediated mRNA stability complex |
| CC | ISS | GO:0071204 | histone pre-mRNA 3'end processing complex |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | TAS | GO:0003690 | double-stranded DNA binding |
| MF | IEA | GO:0003697 | single-stranded DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0051020 | GTPase binding |
Gene expression in normal tissue: YBX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in YBX1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | dbpbpathway | transcriptional activation of dbpb from mrna |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72165 | mRNA Splicing - Minor Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-9017802 | Noncanonical activation of NOTCH3 |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| wikipathways | WP411 | mRNA Processing |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| netpath | Pathway_IL2 | IL2 |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD628 | BRD-K55116708 | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD397 | Pazopanib | 1 |
| iGMDRD354 | Midostaurin | 1 |
| iGMDRD254 | Mdivi-1 | 1 |
| iGMDRD232 | FTI-277 | 1 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD209 | BRD6340 | 1 |
| iGMDRD179 | Shikonin | 1 |
| iGMDRD646 | PHA-793887 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in YBX1
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