ADAM10
Summary: Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADAM metallopeptidase domain 10 | MIM:602192 | Ensembl:ENSG00000137845 | HGNC:HGNC:188 | PA24505 | 15q21.3 |
GO terms in ADAM10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0004175 | endopeptidase activity |
| MF | IMP | GO:0004222 | metalloendopeptidase activity |
| MF | NAS | GO:0004222 | metalloendopeptidase activity |
| MF | TAS | GO:0004222 | metalloendopeptidase activity |
| MF | NAS | GO:0005102 | signaling receptor binding |
| MF | NAS | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008237 | metallopeptidase activity |
| MF | IMP | GO:0008237 | metallopeptidase activity |
| MF | TAS | GO:0008237 | metallopeptidase activity |
| MF | IEA | GO:0017124 | SH3 domain binding |
| MF | ISS | GO:0019901 | protein kinase binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | ISS | GO:0001701 | in utero embryonic development |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006509 | membrane protein ectodomain proteolysis |
| BP | IMP | GO:0006509 | membrane protein ectodomain proteolysis |
| BP | IDA | GO:0007162 | negative regulation of cell adhesion |
| BP | NAS | GO:0007162 | negative regulation of cell adhesion |
| BP | ISS | GO:0007219 | Notch signaling pathway |
| BP | TAS | GO:0007219 | Notch signaling pathway |
| BP | TAS | GO:0007220 | Notch receptor processing |
| BP | NAS | GO:0007229 | integrin-mediated signaling pathway |
| BP | NAS | GO:0007267 | cell-cell signaling |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0010820 | positive regulation of T cell chemotaxis |
| BP | IEA | GO:0016485 | protein processing |
| BP | TAS | GO:0022617 | extracellular matrix disassembly |
| BP | IMP | GO:0030307 | positive regulation of cell growth |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0034612 | response to tumor necrosis factor |
| BP | TAS | GO:0035333 | Notch receptor processing, ligand-dependent |
| BP | IMP | GO:0042117 | monocyte activation |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IMP | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis |
| BP | IDA | GO:0051089 | constitutive protein ectodomain proteolysis |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | ISS | GO:0005634 | nucleus |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005798 | Golgi-associated vesicle |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | HDA | GO:0016020 | membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0035579 | specific granule membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0070821 | tertiary granule membrane |
| CC | IDA | GO:0097038 | perinuclear endoplasmic reticulum |
| CC | IDA | GO:0097197 | tetraspanin-enriched microdomain |
Gene expression in normal tissue: ADAM10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADAM10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980145 | Signaling by NOTCH2 |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant |
| reactome | R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer |
| reactome | R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus |
| biocarta | apppathway | generation of amyloid b-peptide by ps1 |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | notch_pathway | Notch signaling pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP3286 | Copper homeostasis |
| wikipathways | WP3845 | Canonical and Non-canonical Notch signaling |
| wikipathways | WP516 | Hypertrophy Model |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADAM10
CLASSFICATION
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