BCL2
Summary: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
BCL2, apoptosis regulator | MIM:151430 | Ensembl:ENSG00000171791 | HGNC:HGNC:990 | PA25302 | 18q21.33 |
GO terms in BCL2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005739 | mitochondrion |
CC | IBA | GO:0005741 | mitochondrial outer membrane |
CC | IDA | GO:0005741 | mitochondrial outer membrane |
CC | TAS | GO:0005741 | mitochondrial outer membrane |
CC | IDA | GO:0005783 | endoplasmic reticulum |
CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
CC | IEA | GO:0005829 | cytosol |
CC | IDA | GO:0016020 | membrane |
CC | IDA | GO:0031965 | nuclear membrane |
CC | IMP | GO:0032991 | protein-containing complex |
CC | IEA | GO:0043209 | myelin sheath |
CC | IDA | GO:0046930 | pore complex |
BP | IDA | GO:0000209 | protein polyubiquitination |
BP | IEA | GO:0001503 | ossification |
BP | IEA | GO:0001541 | ovarian follicle development |
BP | IEA | GO:0001656 | metanephros development |
BP | IEA | GO:0001658 | branching involved in ureteric bud morphogenesis |
BP | IEA | GO:0001662 | behavioral fear response |
BP | IEA | GO:0001782 | B cell homeostasis |
BP | ISS | GO:0001836 | release of cytochrome c from mitochondria |
BP | NAS | GO:0001836 | release of cytochrome c from mitochondria |
BP | IEA | GO:0001952 | regulation of cell-matrix adhesion |
BP | IEA | GO:0002320 | lymphoid progenitor cell differentiation |
BP | IEA | GO:0002326 | B cell lineage commitment |
BP | IEA | GO:0002931 | response to ischemia |
BP | IEA | GO:0003014 | renal system process |
BP | IEA | GO:0006470 | protein dephosphorylation |
BP | IEA | GO:0006582 | melanin metabolic process |
BP | IEA | GO:0006808 | regulation of nitrogen utilization |
BP | IDA | GO:0006915 | apoptotic process |
BP | TAS | GO:0006959 | humoral immune response |
BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
BP | IEA | GO:0007015 | actin filament organization |
BP | IEA | GO:0007409 | axonogenesis |
BP | NAS | GO:0007565 | female pregnancy |
BP | IEA | GO:0007569 | cell aging |
BP | IEA | GO:0008584 | male gonad development |
BP | IDA | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
BP | IBA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
BP | IEA | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
BP | NAS | GO:0009314 | response to radiation |
BP | IDA | GO:0009636 | response to toxic substance |
BP | IEA | GO:0009791 | post-embryonic development |
BP | IDA | GO:0010039 | response to iron ion |
BP | IEA | GO:0010224 | response to UV-B |
BP | IEA | GO:0010332 | response to gamma radiation |
BP | IEA | GO:0010468 | regulation of gene expression |
BP | TAS | GO:0010507 | negative regulation of autophagy |
BP | IEA | GO:0010523 | negative regulation of calcium ion transport into cytosol |
BP | IEA | GO:0010559 | regulation of glycoprotein biosynthetic process |
BP | IEA | GO:0014031 | mesenchymal cell development |
BP | IEA | GO:0014042 | positive regulation of neuron maturation |
BP | IEA | GO:0014911 | positive regulation of smooth muscle cell migration |
BP | IEA | GO:0018105 | peptidyl-serine phosphorylation |
BP | IEA | GO:0018107 | peptidyl-threonine phosphorylation |
BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
BP | IEA | GO:0021747 | cochlear nucleus development |
BP | IEA | GO:0022612 | gland morphogenesis |
BP | IDA | GO:0022898 | regulation of transmembrane transporter activity |
BP | IEA | GO:0030279 | negative regulation of ossification |
BP | IDA | GO:0030307 | positive regulation of cell growth |
BP | IEA | GO:0030308 | negative regulation of cell growth |
BP | IEA | GO:0030318 | melanocyte differentiation |
BP | IEA | GO:0030336 | negative regulation of cell migration |
BP | IMP | GO:0030890 | positive regulation of B cell proliferation |
BP | IEA | GO:0031069 | hair follicle morphogenesis |
BP | IEA | GO:0031103 | axon regeneration |
BP | IEA | GO:0031647 | regulation of protein stability |
BP | TAS | GO:0032469 | endoplasmic reticulum calcium ion homeostasis |
BP | IEA | GO:0032835 | glomerulus development |
BP | IDA | GO:0032848 | negative regulation of cellular pH reduction |
BP | IEA | GO:0033033 | negative regulation of myeloid cell apoptotic process |
BP | IEA | GO:0033077 | T cell differentiation in thymus |
BP | IEA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
BP | IEA | GO:0033689 | negative regulation of osteoblast proliferation |
BP | IDA | GO:0034097 | response to cytokine |
BP | IDA | GO:0035094 | response to nicotine |
BP | IEA | GO:0035265 | organ growth |
BP | IEA | GO:0040018 | positive regulation of multicellular organism growth |
BP | IDA | GO:0042100 | B cell proliferation |
BP | IEA | GO:0042149 | cellular response to glucose starvation |
BP | IDA | GO:0042493 | response to drug |
BP | IMP | GO:0042493 | response to drug |
BP | IEA | GO:0042542 | response to hydrogen peroxide |
BP | IEA | GO:0043029 | T cell homeostasis |
BP | IBA | GO:0043066 | negative regulation of apoptotic process |
BP | IDA | GO:0043066 | negative regulation of apoptotic process |
BP | IGI | GO:0043066 | negative regulation of apoptotic process |
BP | IMP | GO:0043066 | negative regulation of apoptotic process |
BP | TAS | GO:0043066 | negative regulation of apoptotic process |
BP | IEA | GO:0043085 | positive regulation of catalytic activity |
BP | IEA | GO:0043375 | CD8-positive, alpha-beta T cell lineage commitment |
BP | IDA | GO:0043496 | regulation of protein homodimerization activity |
BP | IDA | GO:0043497 | regulation of protein heterodimerization activity |
BP | IDA | GO:0043524 | negative regulation of neuron apoptotic process |
BP | IEA | GO:0043583 | ear development |
BP | IEA | GO:0045069 | regulation of viral genome replication |
BP | IEA | GO:0045636 | positive regulation of melanocyte differentiation |
BP | IEA | GO:0046671 | negative regulation of retinal cell programmed cell death |
BP | ISS | GO:0046902 | regulation of mitochondrial membrane permeability |
BP | IEA | GO:0048041 | focal adhesion assembly |
BP | IEA | GO:0048536 | spleen development |
BP | IEA | GO:0048538 | thymus development |
BP | IEA | GO:0048546 | digestive tract morphogenesis |
BP | IEA | GO:0048599 | oocyte development |
BP | IEA | GO:0048743 | positive regulation of skeletal muscle fiber development |
BP | IEA | GO:0048753 | pigment granule organization |
BP | IEA | GO:0048873 | homeostasis of number of cells within a tissue |
BP | IMP | GO:0050853 | B cell receptor signaling pathway |
BP | IEA | GO:0051384 | response to glucocorticoid |
BP | TAS | GO:0051402 | neuron apoptotic process |
BP | IDA | GO:0051607 | defense response to virus |
BP | ISS | GO:0051881 | regulation of mitochondrial membrane potential |
BP | TAS | GO:0051902 | negative regulation of mitochondrial depolarization |
BP | IDA | GO:0051924 | regulation of calcium ion transport |
BP | IEA | GO:0055085 | transmembrane transport |
BP | IDA | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
BP | IEA | GO:0071456 | cellular response to hypoxia |
BP | IEA | GO:0072593 | reactive oxygen species metabolic process |
BP | IBA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
BP | IEA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
BP | IEA | GO:0098609 | cell-cell adhesion |
BP | TAS | GO:1900740 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
BP | IEA | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle |
BP | IEA | GO:2000378 | negative regulation of reactive oxygen species metabolic process |
BP | IMP | GO:2000811 | negative regulation of anoikis |
BP | IMP | GO:2001234 | negative regulation of apoptotic signaling pathway |
BP | IGI | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
BP | IBA | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
BP | IDA | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
BP | TAS | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
MF | IDA | GO:0002020 | protease binding |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0008134 | transcription factor binding |
MF | IDA | GO:0015267 | channel activity |
MF | IDA | GO:0016248 | channel inhibitor activity |
MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
MF | IPI | GO:0042802 | identical protein binding |
MF | IBA | GO:0042803 | protein homodimerization activity |
MF | IPI | GO:0042803 | protein homodimerization activity |
MF | IDA | GO:0043565 | sequence-specific DNA binding |
MF | IBA | GO:0046982 | protein heterodimerization activity |
MF | IPI | GO:0046982 | protein heterodimerization activity |
MF | IPI | GO:0051434 | BH3 domain binding |
MF | IEA | GO:0051721 | protein phosphatase 2A binding |
Gene expression in normal tissue: BCL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCL2
Database | Pathway ID | Pathway Des. |
---|---|---|
biocarta | badpathway | regulation of bad phosphorylation |
biocarta | carm1pathway | transcription regulation by methyltransferase of carm1 |
biocarta | ceramidepathway | ceramide signaling pathway |
biocarta | chemicalpathway | apoptotic signaling in response to dna damage |
biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
biocarta | hsp27pathway | stress induction of hsp regulation |
biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
biocarta | il7pathway | il-7 signal transduction |
biocarta | keratinocytepathway | keratinocyte differentiation |
biocarta | melanocytepathway | melanocyte development and pigmentation pathway |
biocarta | mitochondriapathway | role of mitochondria in apoptotic signaling |
biocarta | p53pathway | p53 signaling pathway |
biocarta | prionpathway | prion pathway |
biocarta | telpathway | telomeres telomerase cellular aging and immortality |
reactome | R-HSA-109581 | Apoptosis |
reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
reactome | R-HSA-111447 | Activation of BAD and translocation to mitochondria |
reactome | R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members |
reactome | R-HSA-114452 | Activation of BH3-only proteins |
reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-168249 | Innate Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
reactome | R-HSA-449147 | Signaling by Interleukins |
reactome | R-HSA-5357801 | Programmed Cell Death |
reactome | R-HSA-622312 | Inflammasomes |
reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
reactome | R-HSA-844455 | The NLRP1 inflammasome |
reactome | R-HSA-8939211 | ESR-mediated signaling |
reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
wikipathways | WP127 | IL-5 Signaling Pathway |
wikipathways | WP1438 | Influenza A virus infection |
wikipathways | WP1742 | TP53 Network |
wikipathways | WP1772 | Apoptosis Modulation and Signaling |
wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
wikipathways | WP2447 | Amyotrophic lateral sclerosis (ALS) |
wikipathways | WP2509 | Nanoparticle triggered autophagic cell death |
wikipathways | WP254 | Apoptosis |
wikipathways | WP286 | IL-3 Signaling Pathway |
wikipathways | WP304 | Kit receptor signaling pathway |
wikipathways | WP306 | Focal Adhesion |
wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
wikipathways | WP3287 | Overview of nanoparticle effects |
wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
wikipathways | WP3639 | Apoptotic Signaling Pathway |
wikipathways | WP3657 | Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex |
wikipathways | WP3872 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
wikipathways | WP3941 | Oxidative Damage |
wikipathways | WP3981 | miRNA regulation of prostate cancer signaling pathways |
wikipathways | WP3995 | Prion disease pathway |
wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
wikipathways | WP4066 | Interleukin-4 and 13 signaling |
wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
wikipathways | WP4249 | Hedgehog Signaling Pathway |
wikipathways | WP49 | IL-2 Signaling Pathway |
wikipathways | WP615 | Senescence and Autophagy in Cancer |
wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
wikipathways | WP712 | Estrogen signaling pathway |
pid | atf2_pathway | ATF-2 transcription factor network |
pid | caspase_pathway | Caspase Cascade in Apoptosis |
pid | ceramide_pathway | Ceramide signaling pathway |
pid | cmyb_pathway | C-MYB transcription factor network |
pid | epopathway | EPO signaling pathway |
pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
pid | il2_1pathway | IL2-mediated signaling events |
pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
pid | p53downstreampathway | Direct p53 effectors |
pid | rxr_vdr_pathway | RXR and RAR heterodimerization with other nuclear receptor |
netpath | Pathway_EGFR1 | EGFR1 |
netpath | Pathway_IL2 | IL2 |
netpath | Pathway_IL3 | IL3 |
pharmgkb | PA150981002 | Vinka Alkaloid Pathway, Pharmacokinetics |
pharmgkb | PA165374494 | Busulfan Pathway, Pharmacodynamics |
kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD352 | PD-0325901 | 1 |
iGMDRD329 | Merck60 | 3 |
iGMDRD163 | all trans Retinoic Acid | 1 |
iGMDRD748 | PHA-665752 | 1 |
iGMDRD608 | Refametinib | 1 |
iGMDRD498 | GW441756X | 1 |
iGMDRD690 | PRIMA-1MET | 1 |
iGMDRD832 | BCL2 inhibitor | 2 |
iGMDRD568 | SCHEMBL15005512 | 1 |
iGMDRD387 | CHIR-99021 | 3 |
iGMDRD79 | Gemcitabine | 3 |
iGMDRD781 | Sirolimus | 3 |
iGMDRD427 | ABT737 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCL2