BCL2


Summary: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
BCL2, apoptosis regulatorMIM:151430Ensembl:ENSG00000171791HGNC:HGNC:990PA2530218q21.33

GO terms in BCL2


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCIBAGO:0005741mitochondrial outer membrane
CCIDAGO:0005741mitochondrial outer membrane
CCTASGO:0005741mitochondrial outer membrane
CCIDAGO:0005783endoplasmic reticulum
CCIEAGO:0005789endoplasmic reticulum membrane
CCIEAGO:0005829cytosol
CCIDAGO:0016020membrane
CCIDAGO:0031965nuclear membrane
CCIMPGO:0032991protein-containing complex
CCIEAGO:0043209myelin sheath
CCIDAGO:0046930pore complex
BPIDAGO:0000209protein polyubiquitination
BPIEAGO:0001503ossification
BPIEAGO:0001541ovarian follicle development
BPIEAGO:0001656metanephros development
BPIEAGO:0001658branching involved in ureteric bud morphogenesis
BPIEAGO:0001662behavioral fear response
BPIEAGO:0001782B cell homeostasis
BPISSGO:0001836release of cytochrome c from mitochondria
BPNASGO:0001836release of cytochrome c from mitochondria
BPIEAGO:0001952regulation of cell-matrix adhesion
BPIEAGO:0002320lymphoid progenitor cell differentiation
BPIEAGO:0002326B cell lineage commitment
BPIEAGO:0002931response to ischemia
BPIEAGO:0003014renal system process
BPIEAGO:0006470protein dephosphorylation
BPIEAGO:0006582melanin metabolic process
BPIEAGO:0006808regulation of nitrogen utilization
BPIDAGO:0006915apoptotic process
BPTASGO:0006959humoral immune response
BPIMPGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0007015actin filament organization
BPIEAGO:0007409axonogenesis
BPNASGO:0007565female pregnancy
BPIEAGO:0007569cell aging
BPIEAGO:0008584male gonad development
BPIDAGO:0008625extrinsic apoptotic signaling pathway via death domain receptors
BPIBAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress
BPNASGO:0009314response to radiation
BPIDAGO:0009636response to toxic substance
BPIEAGO:0009791post-embryonic development
BPIDAGO:0010039response to iron ion
BPIEAGO:0010224response to UV-B
BPIEAGO:0010332response to gamma radiation
BPIEAGO:0010468regulation of gene expression
BPTASGO:0010507negative regulation of autophagy
BPIEAGO:0010523negative regulation of calcium ion transport into cytosol
BPIEAGO:0010559regulation of glycoprotein biosynthetic process
BPIEAGO:0014031mesenchymal cell development
BPIEAGO:0014042positive regulation of neuron maturation
BPIEAGO:0014911positive regulation of smooth muscle cell migration
BPIEAGO:0018105peptidyl-serine phosphorylation
BPIEAGO:0018107peptidyl-threonine phosphorylation
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0021747cochlear nucleus development
BPIEAGO:0022612gland morphogenesis
BPIDAGO:0022898regulation of transmembrane transporter activity
BPIEAGO:0030279negative regulation of ossification
BPIDAGO:0030307positive regulation of cell growth
BPIEAGO:0030308negative regulation of cell growth
BPIEAGO:0030318melanocyte differentiation
BPIEAGO:0030336negative regulation of cell migration
BPIMPGO:0030890positive regulation of B cell proliferation
BPIEAGO:0031069hair follicle morphogenesis
BPIEAGO:0031103axon regeneration
BPIEAGO:0031647regulation of protein stability
BPTASGO:0032469endoplasmic reticulum calcium ion homeostasis
BPIEAGO:0032835glomerulus development
BPIDAGO:0032848negative regulation of cellular pH reduction
BPIEAGO:0033033negative regulation of myeloid cell apoptotic process
BPIEAGO:0033077T cell differentiation in thymus
BPIEAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIEAGO:0033689negative regulation of osteoblast proliferation
BPIDAGO:0034097response to cytokine
BPIDAGO:0035094response to nicotine
BPIEAGO:0035265organ growth
BPIEAGO:0040018positive regulation of multicellular organism growth
BPIDAGO:0042100B cell proliferation
BPIEAGO:0042149cellular response to glucose starvation
BPIDAGO:0042493response to drug
BPIMPGO:0042493response to drug
BPIEAGO:0042542response to hydrogen peroxide
BPIEAGO:0043029T cell homeostasis
BPIBAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043066negative regulation of apoptotic process
BPIGIGO:0043066negative regulation of apoptotic process
BPIMPGO:0043066negative regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPIEAGO:0043085positive regulation of catalytic activity
BPIEAGO:0043375CD8-positive, alpha-beta T cell lineage commitment
BPIDAGO:0043496regulation of protein homodimerization activity
BPIDAGO:0043497regulation of protein heterodimerization activity
BPIDAGO:0043524negative regulation of neuron apoptotic process
BPIEAGO:0043583ear development
BPIEAGO:0045069regulation of viral genome replication
BPIEAGO:0045636positive regulation of melanocyte differentiation
BPIEAGO:0046671negative regulation of retinal cell programmed cell death
BPISSGO:0046902regulation of mitochondrial membrane permeability
BPIEAGO:0048041focal adhesion assembly
BPIEAGO:0048536spleen development
BPIEAGO:0048538thymus development
BPIEAGO:0048546digestive tract morphogenesis
BPIEAGO:0048599oocyte development
BPIEAGO:0048743positive regulation of skeletal muscle fiber development
BPIEAGO:0048753pigment granule organization
BPIEAGO:0048873homeostasis of number of cells within a tissue
BPIMPGO:0050853B cell receptor signaling pathway
BPIEAGO:0051384response to glucocorticoid
BPTASGO:0051402neuron apoptotic process
BPIDAGO:0051607defense response to virus
BPISSGO:0051881regulation of mitochondrial membrane potential
BPTASGO:0051902negative regulation of mitochondrial depolarization
BPIDAGO:0051924regulation of calcium ion transport
BPIEAGO:0055085transmembrane transport
BPIDAGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
BPIEAGO:0071456cellular response to hypoxia
BPIEAGO:0072593reactive oxygen species metabolic process
BPIBAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIEAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIEAGO:0098609cell-cell adhesion
BPTASGO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BPIEAGO:2000134negative regulation of G1/S transition of mitotic cell cycle
BPIEAGO:2000378negative regulation of reactive oxygen species metabolic process
BPIMPGO:2000811negative regulation of anoikis
BPIMPGO:2001234negative regulation of apoptotic signaling pathway
BPIGIGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
BPIBAGO:2001243negative regulation of intrinsic apoptotic signaling pathway
BPIDAGO:2001243negative regulation of intrinsic apoptotic signaling pathway
BPTASGO:2001244positive regulation of intrinsic apoptotic signaling pathway
MFIDAGO:0002020protease binding
MFIPIGO:0005515protein binding
MFIEAGO:0008134transcription factor binding
MFIDAGO:0015267channel activity
MFIDAGO:0016248channel inhibitor activity
MFIPIGO:0031625ubiquitin protein ligase binding
MFIPIGO:0042802identical protein binding
MFIBAGO:0042803protein homodimerization activity
MFIPIGO:0042803protein homodimerization activity
MFIDAGO:0043565sequence-specific DNA binding
MFIBAGO:0046982protein heterodimerization activity
MFIPIGO:0046982protein heterodimerization activity
MFIPIGO:0051434BH3 domain binding
MFIEAGO:0051721protein phosphatase 2A binding

Gene expression in normal tissue: BCL2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCL2


DatabasePathway IDPathway Des.
biocartabadpathwayregulation of bad phosphorylation
biocartacarm1pathwaytranscription regulation by methyltransferase of carm1
biocartaceramidepathwayceramide signaling pathway
biocartachemicalpathwayapoptotic signaling in response to dna damage
biocartagleevecpathwayinhibition of cellular proliferation by gleevec
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartahsp27pathwaystress induction of hsp regulation
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartail7pathwayil-7 signal transduction
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamelanocytepathwaymelanocyte development and pigmentation pathway
biocartamitochondriapathwayrole of mitochondria in apoptotic signaling
biocartap53pathwayp53 signaling pathway
biocartaprionpathwayprion pathway
biocartatelpathwaytelomeres telomerase cellular aging and immortality
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111447Activation of BAD and translocation to mitochondria
reactomeR-HSA-111453BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-622312Inflammasomes
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-844455The NLRP1 inflammasome
reactomeR-HSA-8939211ESR-mediated signaling
reactomeR-HSA-9006931Signaling by Nuclear Receptors
reactomeR-HSA-9018519Estrogen-dependent gene expression
wikipathwaysWP127IL-5 Signaling Pathway
wikipathwaysWP1438Influenza A virus infection
wikipathwaysWP1742TP53 Network
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2447Amyotrophic lateral sclerosis (ALS)
wikipathwaysWP2509Nanoparticle triggered autophagic cell death
wikipathwaysWP254Apoptosis
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP3287Overview of nanoparticle effects
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3657Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex
wikipathwaysWP3872Regulation of Apoptosis by Parathyroid Hormone-related Protein
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3941Oxidative Damage
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP3995Prion disease pathway
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP4249Hedgehog Signaling Pathway
wikipathwaysWP49IL-2 Signaling Pathway
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP710DNA Damage Response (only ATM dependent)
wikipathwaysWP712Estrogen signaling pathway
pidatf2_pathwayATF-2 transcription factor network
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidceramide_pathwayCeramide signaling pathway
pidcmyb_pathwayC-MYB transcription factor network
pidepopathwayEPO signaling pathway
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidil2_1pathwayIL2-mediated signaling events
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidmyc_represspathwayValidated targets of C-MYC transcriptional repression
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidp53downstreampathwayDirect p53 effectors
pidrxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
netpathPathway_EGFR1EGFR1
netpathPathway_IL2IL2
netpathPathway_IL3IL3
pharmgkbPA150981002Vinka Alkaloid Pathway, Pharmacokinetics
pharmgkbPA165374494Busulfan Pathway, Pharmacodynamics
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04340Hedgehog signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD352PD-03259011
iGMDRD329Merck603
iGMDRD163all trans Retinoic Acid1
iGMDRD748PHA-6657521
iGMDRD608Refametinib1
iGMDRD498GW441756X1
iGMDRD690PRIMA-1MET1
iGMDRD832BCL2 inhibitor2
iGMDRD568SCHEMBL150055121
iGMDRD387CHIR-990213
iGMDRD79Gemcitabine3
iGMDRD781Sirolimus3
iGMDRD427ABT7373

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL2

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