CHRNB4
Summary: This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cholinergic receptor nicotinic beta 4 subunit | MIM:118509 | Ensembl:ENSG00000117971 | HGNC:HGNC:1964 | PA26496 | 15q25.1 |
GO terms in CHRNB4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001508 | action potential |
| BP | TAS | GO:0006811 | ion transport |
| BP | IEA | GO:0006939 | smooth muscle contraction |
| BP | IEA | GO:0006940 | regulation of smooth muscle contraction |
| BP | IBA | GO:0007165 | signal transduction |
| BP | IDA | GO:0007165 | signal transduction |
| BP | IBA | GO:0007268 | chemical synaptic transmission |
| BP | IBA | GO:0007271 | synaptic transmission, cholinergic |
| BP | TAS | GO:0007271 | synaptic transmission, cholinergic |
| BP | IBA | GO:0007274 | neuromuscular synaptic transmission |
| BP | IEA | GO:0007626 | locomotory behavior |
| BP | IBA | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| BP | IBA | GO:0035094 | response to nicotine |
| BP | IEA | GO:0035095 | behavioral response to nicotine |
| BP | IBA | GO:0042391 | regulation of membrane potential |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | NAS | GO:0046928 | regulation of neurotransmitter secretion |
| BP | IBA | GO:0050877 | nervous system process |
| BP | IEA | GO:0051291 | protein heterooligomerization |
| BP | IEA | GO:0051971 | positive regulation of transmission of nerve impulse |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| BP | IMP | GO:0060084 | synaptic transmission involved in micturition |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IC | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0005892 | acetylcholine-gated channel complex |
| CC | IDA | GO:0005892 | acetylcholine-gated channel complex |
| CC | TAS | GO:0005892 | acetylcholine-gated channel complex |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | TAS | GO:0035579 | specific granule membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IEA | GO:0043005 | neuron projection |
| CC | IBA | GO:0045202 | synapse |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| CC | TAS | GO:0070821 | tertiary granule membrane |
| MF | IBA | GO:0005230 | extracellular ligand-gated ion channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015276 | ligand-gated ion channel activity |
| MF | IBA | GO:0015464 | acetylcholine receptor activity |
| MF | IDA | GO:0015464 | acetylcholine receptor activity |
| MF | IDA | GO:0022848 | acetylcholine-gated cation-selective channel activity |
| MF | TAS | GO:0022848 | acetylcholine-gated cation-selective channel activity |
| MF | IBA | GO:0042166 | acetylcholine binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: CHRNB4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHRNB4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1603 | Nicotine Activity on Chromaffin Cells |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| pharmgkb | PA162355620 | Nicotine Pathway (Chromaffin Cell), Pharmacodynamics |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-181431 | Acetylcholine binding and downstream events |
| reactome | R-HSA-622323 | Presynaptic nicotinic acetylcholine receptors |
| reactome | R-HSA-622327 | Postsynaptic nicotinic acetylcholine receptors |
| reactome | R-HSA-629587 | Highly sodium permeable acetylcholine nicotinic receptors |
| reactome | R-HSA-629594 | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors |
| reactome | R-HSA-629597 | Highly calcium permeable nicotinic acetylcholine receptors |
| reactome | R-HSA-629602 | Activation of Nicotinic Acetylcholine Receptors |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD885 | Compound 110 | 5 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD718 | Pyrvinium pamoate | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHRNB4
CLASSFICATION
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