CHRNB4


Summary: This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cholinergic receptor nicotinic beta 4 subunitMIM:118509Ensembl:ENSG00000117971HGNC:HGNC:1964PA2649615q25.1

GO terms in CHRNB4


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001508action potential
BPTASGO:0006811ion transport
BPIEAGO:0006939smooth muscle contraction
BPIEAGO:0006940regulation of smooth muscle contraction
BPIBAGO:0007165signal transduction
BPIDAGO:0007165signal transduction
BPIBAGO:0007268chemical synaptic transmission
BPIBAGO:0007271synaptic transmission, cholinergic
BPTASGO:0007271synaptic transmission, cholinergic
BPIBAGO:0007274neuromuscular synaptic transmission
BPIEAGO:0007626locomotory behavior
BPIBAGO:0034220ion transmembrane transport
BPIEAGO:0034220ion transmembrane transport
BPIBAGO:0035094response to nicotine
BPIEAGO:0035095behavioral response to nicotine
BPIBAGO:0042391regulation of membrane potential
BPTASGO:0043312neutrophil degranulation
BPNASGO:0046928regulation of neurotransmitter secretion
BPIBAGO:0050877nervous system process
BPIEAGO:0051291protein heterooligomerization
BPIEAGO:0051971positive regulation of transmission of nerve impulse
BPIEAGO:0060079excitatory postsynaptic potential
BPIMPGO:0060084synaptic transmission involved in micturition
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCICGO:0005887integral component of plasma membrane
CCIBAGO:0005892acetylcholine-gated channel complex
CCIDAGO:0005892acetylcholine-gated channel complex
CCTASGO:0005892acetylcholine-gated channel complex
CCNASGO:0016021integral component of membrane
CCIEAGO:0030054cell junction
CCTASGO:0035579specific granule membrane
CCIBAGO:0043005neuron projection
CCIEAGO:0043005neuron projection
CCIBAGO:0045202synapse
CCIEAGO:0045211postsynaptic membrane
CCTASGO:0070821tertiary granule membrane
MFIBAGO:0005230extracellular ligand-gated ion channel activity
MFIPIGO:0005515protein binding
MFTASGO:0015276ligand-gated ion channel activity
MFIBAGO:0015464acetylcholine receptor activity
MFIDAGO:0015464acetylcholine receptor activity
MFIDAGO:0022848acetylcholine-gated cation-selective channel activity
MFTASGO:0022848acetylcholine-gated cation-selective channel activity
MFIBAGO:0042166acetylcholine binding
MFIEAGO:0046982protein heterodimerization activity

Gene expression in normal tissue: CHRNB4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CHRNB4


DatabasePathway IDPathway Des.
wikipathwaysWP1603Nicotine Activity on Chromaffin Cells
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
pharmgkbPA162355620Nicotine Pathway (Chromaffin Cell), Pharmacodynamics
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-181431Acetylcholine binding and downstream events
reactomeR-HSA-622323Presynaptic nicotinic acetylcholine receptors
reactomeR-HSA-622327Postsynaptic nicotinic acetylcholine receptors
reactomeR-HSA-629587Highly sodium permeable acetylcholine nicotinic receptors
reactomeR-HSA-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
reactomeR-HSA-629597Highly calcium permeable nicotinic acetylcholine receptors
reactomeR-HSA-629602Activation of Nicotinic Acetylcholine Receptors
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD121GMX17782
iGMDRD158NSC1415402
iGMDRD885Compound 1105
iGMDRD494Neopeltolide2
iGMDRD424Tamatinib1
iGMDRD427ABT7373
iGMDRD718Pyrvinium pamoate2
iGMDRD562Navitoclax2
iGMDRD882CIL412
iGMDRD353PD03259011
iGMDRD322FK 8662
iGMDRD466Chaetocin2
iGMDRD177Teniposide2
iGMDRD123Isoevodiamine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CHRNB4

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