CSF3R


Summary: The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
colony stimulating factor 3 receptorMIM:138971Ensembl:ENSG00000119535HGNC:HGNC:2439PA269421p34.3

Gene Categories:

DRUGGABLE GENOME

GO terms in CSF3R


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004896cytokine receptor activity
MFIEAGO:0004896cytokine receptor activity
MFIBAGO:0004912interleukin-3 receptor activity
MFIPIGO:0005515protein binding
MFIBAGO:0019955cytokine binding
MFIBAGO:0019978interleukin-3 binding
MFTASGO:0038023signaling receptor activity
MFIEAGO:0051916granulocyte colony-stimulating factor binding
CCIEAGO:0005576extracellular region
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIBAGO:0009897external side of plasma membrane
CCIBAGO:0043235receptor complex
BPTASGO:0006952defense response
BPIEAGO:0007155cell adhesion
BPNASGO:0007165signal transduction
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0030593neutrophil chemotaxis
BPIEAGO:0045637regulation of myeloid cell differentiation
BPIEAGO:0097186amelogenesis

Gene expression in normal tissue: CSF3R

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CSF3R


DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449836Other interleukin signaling
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD870BRD636102
iGMDRD574Ruxolitinib2
iGMDRD231Importazole3
iGMDRD150RITA2
iGMDRD239Dasatinib12
iGMDRD512nutlin 31
iGMDRD353PD03259011
iGMDRD886Compound 1541A3
iGMDRD123Isoevodiamine3
iGMDRD506Fedratinib1
iGMDRD366PI-1031
iGMDRD237ABT-7513
iGMDRD152179324-69-74
iGMDRD188Piperlongumine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CSF3R

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