CYP3A4
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cytochrome P450 family 3 subfamily A member 4 | MIM:124010 | Ensembl:ENSG00000160868 | HGNC:HGNC:2637 | PA130 | 7q22.1 |
GO terms in CYP3A4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004497 | monooxygenase activity |
| MF | ISS | GO:0004497 | monooxygenase activity |
| MF | TAS | GO:0004497 | monooxygenase activity |
| MF | IDA | GO:0005496 | steroid binding |
| MF | IDA | GO:0005506 | iron ion binding |
| MF | IMP | GO:0008395 | steroid hydroxylase activity |
| MF | IDA | GO:0016491 | oxidoreductase activity |
| MF | IEA | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| MF | TAS | GO:0019825 | oxygen binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0020037 | heme binding |
| MF | IDA | GO:0030343 | vitamin D3 25-hydroxylase activity |
| MF | IDA | GO:0034875 | caffeine oxidase activity |
| MF | IMP | GO:0050649 | testosterone 6-beta-hydroxylase activity |
| MF | IDA | GO:0070576 | vitamin D 24-hydroxylase activity |
| MF | IDA | GO:0101020 | estrogen 16-alpha-hydroxylase activity |
| BP | IDA | GO:0002933 | lipid hydroxylation |
| BP | TAS | GO:0006629 | lipid metabolic process |
| BP | IMP | GO:0006706 | steroid catabolic process |
| BP | TAS | GO:0006805 | xenobiotic metabolic process |
| BP | IDA | GO:0008202 | steroid metabolic process |
| BP | IMP | GO:0008202 | steroid metabolic process |
| BP | TAS | GO:0008209 | androgen metabolic process |
| BP | IDA | GO:0009822 | alkaloid catabolic process |
| BP | IDA | GO:0016098 | monoterpenoid metabolic process |
| BP | IDA | GO:0017144 | drug metabolic process |
| BP | IEA | GO:0036378 | calcitriol biosynthetic process from calciol |
| BP | IC | GO:0042359 | vitamin D metabolic process |
| BP | IDA | GO:0042737 | drug catabolic process |
| BP | IMP | GO:0042737 | drug catabolic process |
| BP | IDA | GO:0042738 | exogenous drug catabolic process |
| BP | TAS | GO:0042759 | long-chain fatty acid biosynthetic process |
| BP | IDA | GO:0046483 | heterocycle metabolic process |
| BP | IDA | GO:0055114 | oxidation-reduction process |
| BP | IDA | GO:0070989 | oxidative demethylation |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031090 | organelle membrane |
| CC | TAS | GO:0043231 | intracellular membrane-bounded organelle |
Gene expression in normal tissue: CYP3A4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CYP3A4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1604 | Codeine and Morphine Metabolism |
| wikipathways | WP206 | Fatty Acid Omega Oxidation |
| wikipathways | WP2289 | Drug Induction of Bile Acid Pathway |
| wikipathways | WP229 | Irinotecan Pathway |
| wikipathways | WP259 | Nifedipine Activity |
| wikipathways | WP2646 | Lidocaine metabolism |
| wikipathways | WP2816 | Felbamate Metabolism |
| wikipathways | WP2826 | Cocaine metabolism |
| wikipathways | WP2874 | Liver X Receptor Pathway |
| wikipathways | WP2875 | Constitutive Androstane Receptor Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP2879 | Farnesoid X Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP299 | Nuclear Receptors in Lipid Metabolism and Toxicity |
| wikipathways | WP3869 | Cannabinoid receptor signaling |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP43 | Oxidation by Cytochrome P450 |
| wikipathways | WP465 | Tryptophan metabolism |
| wikipathways | WP691 | Tamoxifen metabolism |
| wikipathways | WP696 | Benzo(a)pyrene metabolism |
| wikipathways | WP697 | Estrogen metabolism |
| wikipathways | WP699 | Aflatoxin B1 metabolism |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| smpdb | SMP00028 | Caffeine Metabolism |
| smpdb | SMP00074 | Retinol Metabolism |
| smpdb | SMP00086 | Ibuprofen Action Pathway |
| smpdb | SMP00096 | Celecoxib Action Pathway |
| smpdb | SMP00260 | Clopidogrel Action Pathway |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00328 | Lidocaine (Antiarrhythmic) Action Pathway |
| smpdb | SMP00336 | Vitamin A Deficiency |
| smpdb | SMP00398 | Lidocaine (Local Anaesthetic) Action Pathway |
| smpdb | SMP00405 | Codeine Action Pathway |
| smpdb | SMP00408 | Methadone Action Pathway |
| smpdb | SMP00422 | Imipramine Action Pathway |
| smpdb | SMP00426 | Fluoxetine Action Pathway |
| smpdb | SMP00433 | Irinotecan Action Pathway |
| smpdb | SMP00436 | Vinblastine Action Pathway |
| smpdb | SMP00439 | Vinorelbine Action Pathway |
| smpdb | SMP00440 | Prednisone Action Pathway |
| smpdb | SMP00442 | Etoposide Action Pathway |
| smpdb | SMP00443 | Teniposide Action Pathway |
| smpdb | SMP00447 | Cyclophosphamide Action Pathway |
| smpdb | SMP00448 | Ifosfamide Action Pathway |
| smpdb | SMP00471 | Tamoxifen Action Pathway |
| smpdb | SMP00590 | Ibuprofen Metabolism Pathway |
| smpdb | SMP00600 | Irinotecan Metabolism Pathway |
| smpdb | SMP00601 | Etoposide Metabolism Pathway |
| smpdb | SMP00602 | Teniposide Metabolism Pathway |
| smpdb | SMP00604 | Cyclophosphamide Metabolism Pathway |
| smpdb | SMP00605 | Ifosfamide Metabolism Pathway |
| smpdb | SMP00606 | Tamoxifen Metabolism Pathway |
| smpdb | SMP00610 | Clopidogrel Metabolism Pathway |
| smpdb | SMP00620 | Lidocaine (Local Anaesthetic) Metabolism Pathway |
| smpdb | SMP00621 | Codeine Metabolism Pathway |
| smpdb | SMP00624 | Methadone Metabolism Pathway |
| smpdb | SMP00625 | Imipramine Metabolism Pathway |
| smpdb | SMP00631 | Prednisone Metabolism Pathway |
| smpdb | SMP00633 | Felbamate Metabolism Pathway |
| smpdb | SMP00634 | Carbamazepine Metabolism Pathway |
| smpdb | SMP00636 | Venlafaxine Metabolism Pathway |
| smpdb | SMP00637 | Tramadol Metabolism Pathway |
| smpdb | SMP00639 | Clomipramine Metabolism Pathway |
| smpdb | SMP00640 | Acetaminophen Metabolism Pathway |
| smpdb | SMP00641 | Doxepin Metabolism Pathway |
| smpdb | SMP00642 | Nevirapine Metabolism Pathway |
| smpdb | SMP00644 | Celecoxib Metabolism Pathway |
| smpdb | SMP00646 | Fluoxetine Metabolism Pathway |
| smpdb | SMP00648 | Sorafenib Metabolism Pathway |
| smpdb | SMP00651 | Artemether Metabolism Pathway |
| smpdb | SMP00652 | Mycophenolic Acid Metabolism Pathway |
| kegg | hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| kegg | hsa00591 | Linoleic acid metabolism - Homo sapiens (human) |
| kegg | hsa00830 | Retinol metabolism - Homo sapiens (human) |
| kegg | hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
| pharmgkb | PA145011108 | Statin Pathway - Generalized, Pharmacokinetics |
| pharmgkb | PA145011109 | Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics |
| pharmgkb | PA145011111 | Fluvastatin Pathway, Pharmacokinetics |
| pharmgkb | PA145011113 | Warfarin Pathway, Pharmacokinetics |
| pharmgkb | PA145011115 | Phenytoin Pathway, Pharmacokinetics |
| pharmgkb | PA145011119 | Tamoxifen Pathway, Pharmacokinetics |
| pharmgkb | PA146123006 | Codeine and Morphine Pathway, Pharmacokinetics |
| pharmgkb | PA150981002 | Vinka Alkaloid Pathway, Pharmacokinetics |
| pharmgkb | PA152325160 | Gefitinib Pathway, Pharmacokinetics |
| pharmgkb | PA152530846 | Proton Pump Inhibitor Pathway, Pharmacokinetics |
| pharmgkb | PA153627759 | Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics |
| pharmgkb | PA154423659 | Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics |
| pharmgkb | PA154424674 | Clopidogrel Pathway, Pharmacokinetics |
| pharmgkb | PA154426155 | Taxane Pathway, Pharmacokinetics |
| pharmgkb | PA154426903 | Erlotinib Pathway, Pharmacokinetics |
| pharmgkb | PA161749012 | Fluoxetine Pathway, Pharmacokinetics |
| pharmgkb | PA162359940 | Imipramine/Desipramine Pathway, Pharmacokinetics |
| pharmgkb | PA164713427 | Imatinib Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA164713428 | Losartan Pathway, Pharmacokinetics |
| pharmgkb | PA164713429 | Citalopram Pathway, Pharmacokinetics |
| pharmgkb | PA165111375 | Benzodiazepine Pathway, Pharmacokinetics |
| pharmgkb | PA165378192 | Artemisinin and Derivatives Pathway, Pharmacokinetics |
| pharmgkb | PA165816736 | Celecoxib Pathway, Pharmacokinetics |
| pharmgkb | PA165817070 | Carbamazepine Pathway, Pharmacokinetics |
| pharmgkb | PA165859361 | Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA165884757 | Caffeine Pathway, Pharmacokinetics |
| pharmgkb | PA165946349 | Tramadol Pharmacokinetics |
| pharmgkb | PA165948566 | Metformin Pathway, Pharmacodynamic |
| pharmgkb | PA165950411 | Nevirapine Pathway, Pharmacokinetics |
| pharmgkb | PA165958541 | Theophylline Pathway, Pharmacokinetics |
| pharmgkb | PA165959537 | Sorafenib Pharmacokinetics |
| pharmgkb | PA165960076 | Clomipramine Pathway, Pharmacokinetics |
| pharmgkb | PA165964832 | Mycophenolic acid Pathway, Pharmacokinetics |
| pharmgkb | PA165964832 | Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA165981686 | Doxepin Pathway, Pharmacokinetics |
| pharmgkb | PA165986114 | Tacrolimus/Cyclosporine Pathway, Pharmacokinetics |
| pharmgkb | PA165986194 | Pathway_PA165986194 -need delete |
| pharmgkb | PA165986279 | Acetaminophen Pathway, Pharmacokinetics |
| pharmgkb | PA166014758 | Venlafaxine Pathway, Pharmacokinetics |
| pharmgkb | PA166041114 | Ibuprofen Pathway, Pharmacokinetics |
| pharmgkb | PA2001 | Irinotecan Pathway, Pharmacokinetics |
| pharmgkb | PA2025 | Etoposide Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA2034 | Cyclophosphamide Pathway, Pharmacokinetics |
| pharmgkb | PA2037 | Ifosfamide Pathway, Pharmacokinetics |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-211897 | Cytochrome P450 - arranged by substrate type |
| reactome | R-HSA-211945 | Phase I - Functionalization of compounds |
| reactome | R-HSA-211981 | Xenobiotics |
| reactome | R-HSA-5423646 | Aflatoxin activation and detoxification |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-9018677 | Biosynthesis of DHA-derived SPMs |
| reactome | R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) |
| reactome | R-HSA-9018682 | Biosynthesis of maresins |
| reactome | R-HSA-9027307 | Biosynthesis of maresin-like SPMs |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD882 | CIL41 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD150 | RITA | 7 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CYP3A4
CLASSFICATION
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