GO terms in FRS2


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005068transmembrane receptor protein tyrosine kinase adaptor activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005104fibroblast growth factor receptor binding
MFIPIGO:0005168neurotrophin TRKA receptor binding
MFIPIGO:0005515protein binding
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFTASGO:0019211phosphatase activator activity
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
BPTASGO:0000165MAPK cascade
BPTASGO:0000186activation of MAPKK activity
BPIEAGO:0000187activation of MAPK activity
BPIEAGO:0001702gastrulation with mouth forming second
BPIEAGO:0001759organ induction
BPIEAGO:0003281ventricular septum development
BPTASGO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0007405neuroblast proliferation
BPTASGO:0007411axon guidance
BPIGIGO:0008543fibroblast growth factor receptor signaling pathway
BPTASGO:0008543fibroblast growth factor receptor signaling pathway
BPIEAGO:0008595anterior/posterior axis specification, embryo
BPIEAGO:0030900forebrain development
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIEAGO:0042981regulation of apoptotic process
BPIEAGO:0046619optic placode formation involved in camera-type eye formation
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPTASGO:0048011neurotrophin TRK receptor signaling pathway
BPIEAGO:0050678regulation of epithelial cell proliferation
BPTASGO:0051897positive regulation of protein kinase B signaling
BPIEAGO:0060527prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
BPIEAGO:0070307lens fiber cell development
BPIEAGO:0070372regulation of ERK1 and ERK2 cascade
BPIGIGO:2000726negative regulation of cardiac muscle cell differentiation
CCTASGO:0005768endosome
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIDAGO:0005913cell-cell adherens junction
CCTASGO:0016020membrane

Gene expression in normal tissue: FRS2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FRS2


DatabasePathway IDPathway Des.
wikipathwaysWP1993Angiogenesis overview
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
pidfgf_pathwayFGF signaling pathway
pidret_pathwaySignaling events regulated by Ret tyrosine kinase
pidshp2_pathwaySHP2 signaling
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
netpathPathway_BDNFBDNF
netpathPathway_EGFR1EGFR1
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-169893Prolonged ERK activation events
reactomeR-HSA-169893Prolonged ERK activation events
reactomeR-HSA-170968Frs2-mediated activation
reactomeR-HSA-170968Frs2-mediated activation
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5654687Downstream signaling of activated FGFR1
reactomeR-HSA-5654689PI-3K cascade:FGFR1
reactomeR-HSA-5654693FRS-mediated FGFR1 signaling
reactomeR-HSA-5654695PI-3K cascade:FGFR2
reactomeR-HSA-5654696Downstream signaling of activated FGFR2
reactomeR-HSA-5654700FRS-mediated FGFR2 signaling
reactomeR-HSA-5654706FRS-mediated FGFR3 signaling
reactomeR-HSA-5654708Downstream signaling of activated FGFR3
reactomeR-HSA-5654710PI-3K cascade:FGFR3
reactomeR-HSA-5654712FRS-mediated FGFR4 signaling
reactomeR-HSA-5654716Downstream signaling of activated FGFR4
reactomeR-HSA-5654720PI-3K cascade:FGFR4
reactomeR-HSA-5654726Negative regulation of FGFR1 signaling
reactomeR-HSA-5654727Negative regulation of FGFR2 signaling
reactomeR-HSA-5654732Negative regulation of FGFR3 signaling
reactomeR-HSA-5654733Negative regulation of FGFR4 signaling
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-5654741Signaling by FGFR3
reactomeR-HSA-5654743Signaling by FGFR4
reactomeR-HSA-5655253Signaling by FGFR2 in disease
reactomeR-HSA-5655291Signaling by FGFR4 in disease
reactomeR-HSA-5655302Signaling by FGFR1 in disease
reactomeR-HSA-5655332Signaling by FGFR3 in disease
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-8853334Signaling by FGFR3 fusions in cancer
reactomeR-HSA-8853338Signaling by FGFR3 point mutants in cancer
reactomeR-HSA-8853659RET signaling
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9028731Activated NTRK2 signals through FRS2 and FRS3
reactomeR-HSA-9028731Activated NTRK2 signals through FRS2 and FRS3

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD103SN-385
iGMDRD330BRD41321
iGMDRD116CD4375
iGMDRD494Neopeltolide1
iGMDRD446LY 21832401
iGMDRD188Piperlongumine1
iGMDRD911FGFR inhibitor2
iGMDRD780PP-303
iGMDRD60Quinoclamine4
iGMDRD634SCHEMBL26080415
iGMDRD268Cerulenin1
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD154NSC237663

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FRS2

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