NPR1
Summary: Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| natriuretic peptide receptor 1 | MIM:108960 | Ensembl:ENSG00000169418 | HGNC:HGNC:7943 | PA31736 | 1q21.3 |
GO terms in NPR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006182 | cGMP biosynthetic process |
| BP | IDA | GO:0006182 | cGMP biosynthetic process |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007165 | signal transduction |
| BP | NAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | IDA | GO:0007168 | receptor guanylyl cyclase signaling pathway |
| BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007589 | body fluid secretion |
| BP | NAS | GO:0008217 | regulation of blood pressure |
| BP | IBA | GO:0009190 | cyclic nucleotide biosynthetic process |
| BP | TAS | GO:0016525 | negative regulation of angiogenesis |
| BP | NAS | GO:0030308 | negative regulation of cell growth |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0035810 | positive regulation of urine volume |
| BP | TAS | GO:0035815 | positive regulation of renal sodium excretion |
| BP | IEA | GO:0042417 | dopamine metabolic process |
| BP | TAS | GO:0043114 | regulation of vascular permeability |
| BP | IEA | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| BP | NAS | GO:0097746 | regulation of blood vessel diameter |
| BP | TAS | GO:1903779 | regulation of cardiac conduction |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0008074 | guanylate cyclase complex, soluble |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0043235 | receptor complex |
| MF | IBA | GO:0004016 | adenylate cyclase activity |
| MF | IBA | GO:0004383 | guanylate cyclase activity |
| MF | IDA | GO:0004383 | guanylate cyclase activity |
| MF | IEA | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | NAS | GO:0008528 | G-protein coupled peptide receptor activity |
| MF | IDA | GO:0016941 | natriuretic peptide receptor activity |
| MF | IPI | GO:0017046 | peptide hormone binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0042562 | hormone binding |
Gene expression in normal tissue: NPR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NPR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5578768 | Physiological factors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD634 | SCHEMBL2608041 | 6 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD103 | SN-38 | 8 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD307 | Manumycin A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NPR1
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