OR4E2
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| olfactory receptor family 4 subfamily E member 2 | Ensembl:ENSG00000221977 | HGNC:HGNC:8297 | PA32278 | 14q11.2 |
GO terms in OR4E2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell |
| CC | TAS | GO:0005886 | plasma membrane |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IEA | GO:0004930 | G-protein coupled receptor activity |
| MF | IEA | GO:0004984 | olfactory receptor activity |
Gene expression in normal tissue: OR4E2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in OR4E2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04740 | Olfactory transduction - Homo sapiens (human) |
| wikipathways | WP3608 | Olfactory receptor activity |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD341 | Triacsin c | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in OR4E2
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