PAK4


Summary: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
p21 (RAC1) activated kinase 4MIM:605451Ensembl:ENSG00000130669HGNC:HGNC:16059PA3292019q13.2

GO terms in PAK4


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIMPGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0048365Rac GTPase binding
MFHDAGO:0098641cadherin binding involved in cell-cell adhesion
BPTASGO:0001558regulation of cell growth
BPTASGO:0006915apoptotic process
BPTASGO:0007010cytoskeleton organization
BPIEAGO:0007049cell cycle
BPTASGO:0007165signal transduction
BPIBAGO:0007266Rho protein signal transduction
BPIBAGO:0007346regulation of mitotic cell cycle
BPTASGO:0008283cell proliferation
BPIBAGO:0016477cell migration
BPTASGO:0016477cell migration
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIBAGO:0030036actin cytoskeleton organization
BPIBAGO:0032147activation of protein kinase activity
BPIBAGO:0043408regulation of MAPK cascade
BPIMPGO:0045766positive regulation of angiogenesis
BPIEAGO:0060996dendritic spine development
BPIEAGO:0071407cellular response to organic cyclic compound
BPIEAGO:0098609cell-cell adhesion
BPIMPGO:2000352negative regulation of endothelial cell apoptotic process
CCIBAGO:0005737cytoplasm
CCTASGO:0005794Golgi apparatus
CCHDAGO:0005913cell-cell adherens junction
CCHDAGO:0005925focal adhesion

Gene expression in normal tissue: PAK4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PAK4


DatabasePathway IDPathway Des.
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP306Focal Adhesion
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP4223Ras Signaling
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP673ErbB Signaling Pathway
pidcdc42_pathwayCDC42 signaling events
pidfgf_pathwayFGF signaling pathway
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
biocartaagrpathwayagrin in postsynaptic differentiation
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-428540Activation of RAC1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD158NSC1415402
iGMDRD1008SR-II-138A3
iGMDRD427ABT7371
iGMDRD424Tamatinib2
iGMDRD560MK-22063
iGMDRD116CD4371
iGMDRD77Itraconazole2
iGMDRD481Dactolisib3
iGMDRD506Fedratinib2
iGMDRD369TGX-1153
iGMDRD60Quinoclamine2
iGMDRD511CHEMBL3993793

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PAK4

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