PSMA4


Summary: This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
proteasome subunit alpha 4MIM:176846Ensembl:ENSG00000041357HGNC:HGNC:9533PA3387815q25.1

GO terms in PSMA4


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004175endopeptidase activity
MFIEAGO:0004298threonine-type endopeptidase activity
MFIPIGO:0005515protein binding
BPIEAGO:0006511ubiquitin-dependent protein catabolic process
BPIBAGO:0010498proteasomal protein catabolic process
BPIBAGO:0010499proteasomal ubiquitin-independent protein catabolic process
BPIEAGO:0016032viral process
BPTASGO:0016579protein deubiquitination
BPIBAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPTASGO:0043687post-translational protein modification
CCIDAGO:0000502proteasome complex
CCISSGO:0000932P-body
CCHDAGO:0005634nucleus
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0005839proteasome core complex
CCISSGO:0005839proteasome core complex
CCIBAGO:0019773proteasome core complex, alpha-subunit complex
CCISSGO:0019773proteasome core complex, alpha-subunit complex
CCIDAGO:0043231intracellular membrane-bounded organelle
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: PSMA4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PSMA4


DatabasePathway IDPathway Des.
kegghsa03050Proteasome - Homo sapiens (human)
wikipathwaysWP183Proteasome Degradation
wikipathwaysWP410Exercise-induced Circadian Regulation
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygen
reactomeR-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
reactomeR-HSA-1236974ER-Phagosome pathway
reactomeR-HSA-1236975Antigen processing-Cross presentation
reactomeR-HSA-1236975Antigen processing-Cross presentation
reactomeR-HSA-1236978Cross-presentation of soluble exogenous antigens (endosomes)
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162909Host Interactions of HIV factors
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1643685Disease
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-169911Regulation of Apoptosis
reactomeR-HSA-174084Autodegradation of Cdh1 by Cdh1:APC/C
reactomeR-HSA-174113SCF-beta-TrCP mediated degradation of Emi1
reactomeR-HSA-174143APC/C-mediated degradation of cell cycle proteins
reactomeR-HSA-174154APC/C:Cdc20 mediated degradation of Securin
reactomeR-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
reactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin A
reactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphase
reactomeR-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteins
reactomeR-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
reactomeR-HSA-179419APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
reactomeR-HSA-180534Vpu mediated degradation of CD4
reactomeR-HSA-180585Vif-mediated degradation of APOBEC3G
reactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21
reactomeR-HSA-195253Degradation of beta-catenin by the destruction complex
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-211733Regulation of activated PAK-2p34 by proteasome mediated degradation
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262749Cellular response to hypoxia
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2467813Separation of Sister Chromatids
reactomeR-HSA-2555396Mitotic Metaphase and Anaphase
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-349425Autodegradation of the E3 ubiquitin ligase COP1
reactomeR-HSA-350562Regulation of ornithine decarboxylase (ODC)
reactomeR-HSA-351202Metabolism of polyamines
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-382556ABC-family proteins mediated transport
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4086400PCP/CE pathway
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450408AUF1 (hnRNP D0) binds and destabilizes mRNA
reactomeR-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elements
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453276Regulation of mitotic cell cycle
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-4608870Asymmetric localization of PCP proteins
reactomeR-HSA-4641257Degradation of AXIN
reactomeR-HSA-4641258Degradation of DVL
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5358346Hedgehog ligand biogenesis
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5362768Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
reactomeR-HSA-5387390Hh mutants abrogate ligand secretion
reactomeR-HSA-5607761Dectin-1 mediated noncanonical NF-kB signaling
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5610780Degradation of GLI1 by the proteasome
reactomeR-HSA-5610783Degradation of GLI2 by the proteasome
reactomeR-HSA-5610785GLI3 is processed to GLI3R by the proteasome
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-5619084ABC transporter disorders
reactomeR-HSA-5619115Disorders of transmembrane transporters
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5632684Hedgehog 'on' state
reactomeR-HSA-5658442Regulation of RAS by GAPs
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5676590NIK-->noncanonical NF-kB signaling
reactomeR-HSA-5678895Defective CFTR causes cystic fibrosis
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-5687128MAPK6/MAPK4 signaling
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689603UCH proteinases
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-68827CDT1 association with the CDC6:ORC:origin complex
reactomeR-HSA-68867Assembly of the pre-replicative complex
reactomeR-HSA-68874M/G1 Transition
reactomeR-HSA-68882Mitotic Anaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-68949Orc1 removal from chromatin
reactomeR-HSA-69002DNA Replication Pre-Initiation
reactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6
reactomeR-HSA-69052Switching of origins to a post-replicative state
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69229Ubiquitin-dependent degradation of Cyclin D1
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69242S Phase
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69541Stabilization of p53
reactomeR-HSA-69563p53-Dependent G1 DNA Damage Response
reactomeR-HSA-69580p53-Dependent G1/S DNA damage checkpoint
reactomeR-HSA-69601Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
reactomeR-HSA-69610p53-Independent DNA Damage Response
reactomeR-HSA-69613p53-Independent G1/S DNA damage checkpoint
reactomeR-HSA-69615G1/S DNA Damage Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-71291Metabolism of amino acids and derivatives
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin D
reactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpoint
reactomeR-HSA-8854050FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCs
reactomeR-HSA-8939902Regulation of RUNX2 expression and activity
reactomeR-HSA-8939902Regulation of RUNX2 expression and activity
reactomeR-HSA-8941858Regulation of RUNX3 expression and activity
reactomeR-HSA-8948751Regulation of PTEN stability and activity
reactomeR-HSA-8951664Neddylation
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
reactomeR-HSA-9013694Signaling by NOTCH4
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-9604323Negative regulation of NOTCH4 signaling
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
biocartaproteasomepathwayproteasome complex

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD870BRD636104
iGMDRD187BRD98763
iGMDRD781Sirolimus6
iGMDRD885Compound 1102
iGMDRD772BRD47703
iGMDRD425ERASTIN3
iGMDRD307Manumycin A3
iGMDRD84Lovastatin acid3
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD147Prima-13
iGMDRD690PRIMA-1MET3
iGMDRD780PP-303
iGMDRD882CIL413
iGMDRD887Compound 23 citrate3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PSMA4

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