SIK1


Summary: This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30. [provided by RefSeq, Nov 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
salt inducible kinase 1MIM:605705Ensembl:ENSG00000142178HGNC:HGNC:11142PA16472571721q22.3

GO terms in SIK1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000287magnesium ion binding
MFISSGO:0000287magnesium ion binding
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFISSGO:0005524ATP binding
MFISSGO:0008140cAMP response element binding protein binding
MFIPIGO:0019901protein kinase binding
MFIDAGO:007188914-3-3 protein binding
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCISSGO:0005737cytoplasm
CCIBAGO:0031588nucleotide-activated protein kinase complex
BPISSGO:0002028regulation of sodium ion transport
BPIBAGO:0006468protein phosphorylation
BPIDAGO:0006468protein phosphorylation
BPISSGO:0006468protein phosphorylation
BPIEAGO:0007049cell cycle
BPISSGO:0007346regulation of mitotic cell cycle
BPISSGO:0010830regulation of myotube differentiation
BPISSGO:0010868negative regulation of triglyceride biosynthetic process
BPIBAGO:0032007negative regulation of TOR signaling
BPISSGO:0032792negative regulation of CREB transcription factor activity
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0035556intracellular signal transduction
BPISSGO:0035556intracellular signal transduction
BPIBAGO:0042149cellular response to glucose starvation
BPISSGO:0043153entrainment of circadian clock by photoperiod
BPISSGO:0045595regulation of cell differentiation
BPISSGO:0045721negative regulation of gluconeogenesis
BPIDAGO:0046777protein autophosphorylation
BPIEAGO:0048511rhythmic process
BPISSGO:0055007cardiac muscle cell differentiation
BPIMPGO:2000210positive regulation of anoikis

Gene expression in normal tissue: SIK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SIK1


DatabasePathway IDPathway Des.
reactomeR-HSA-400253Circadian Clock
wikipathwaysWP366TGF-beta Signaling Pathway
pidlkb1_pathwayLKB1 signaling events
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD138PX 123
iGMDRD137Indisulam1
iGMDRD148Pifithrin-mu3
iGMDRD427ABT7374
iGMDRD577BIX012944
iGMDRD152179324-69-73
iGMDRD562Navitoclax2
iGMDRD297Austocystin D1
iGMDRD300Tozasertib4
iGMDRD263AACOCF31

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SIK1

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