SS18L1


Summary: This gene encodes a calcium-responsive transactivator which is an essential subunit of a neuron-specific chromatin-remodeling complex. The structure of this gene is similar to that of the SS18 gene. Mutations in this gene are involved in amyotrophic lateral sclerosis (ALS). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SS18L1, nBAF chromatin remodeling complex subunitMIM:606472Ensembl:ENSG00000184402HGNC:HGNC:15592PA3798920q13.33

GO terms in SS18L1


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003712transcription coregulator activity
MFIEAGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
CCIDAGO:0000776kinetochore
CCIEAGO:0000777condensed chromosome kinetochore
CCIEAGO:0000780condensed nuclear chromosome, centromeric region
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCISSGO:0005634nucleus
CCIDAGO:0005829cytosol
CCIEAGO:0016604nuclear body
CCIEAGO:0071565nBAF complex
BPIEAGO:0006325chromatin organization
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0016358dendrite development
BPIBAGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIBAGO:0050775positive regulation of dendrite morphogenesis
BPIEAGO:0050775positive regulation of dendrite morphogenesis

Gene expression in normal tissue: SS18L1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SS18L1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD158NSC1415402
iGMDRD137Indisulam2
iGMDRD405PIK-752
iGMDRD427ABT7372
iGMDRD546BMS-7548072
iGMDRD434BMS-5369242
iGMDRD577BIX012942
iGMDRD297Austocystin D2
iGMDRD679Bistramide A3
iGMDRD60Quinoclamine2
iGMDRD394BX-7952
iGMDRD280CYTOCHALASIN B4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SS18L1

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