STK38
Summary: This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serine/threonine kinase 38 | MIM:606964 | Ensembl:ENSG00000112079 | HGNC:HGNC:17847 | PA38251 | 6p21.31 |
GO terms in STK38
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006464 | cellular protein modification process |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0043407 | negative regulation of MAP kinase activity |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IPI | GO:0031435 | mitogen-activated protein kinase kinase kinase binding |
| MF | HDA | GO:0045296 | cadherin binding |
Gene expression in normal tissue: STK38
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STK38
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2916 | Interactome of polycomb repressive complex 2 (PRC2) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD427 | ABT737 | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STK38
CLASSFICATION
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