Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017].

toll like receptor 9MIM:605474Ensembl:ENSG00000239732HGNC:HGNC:15633PA380103p21.2

GO terms in TLR9

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004888transmembrane signaling receptor activity
MFIPIGO:0005149interleukin-1 receptor binding
MFIBAGO:0008329signaling pattern recognition receptor activity
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFIMPGO:0035197siRNA binding
MFISSGO:0042803protein homodimerization activity
MFISSGO:0045322unmethylated CpG binding
CCTASGO:0000139Golgi membrane
CCNASGO:0005576extracellular region
CCISSGO:0005783endoplasmic reticulum
CCTASGO:0005789endoplasmic reticulum membrane
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0010008endosome membrane
CCIEAGO:0016021integral component of membrane
CCIDAGO:0016323basolateral plasma membrane
CCIDAGO:0016324apical plasma membrane
CCISSGO:0032009early phagosome
CCTASGO:0036020endolysosome membrane
BPIBAGO:0002224toll-like receptor signaling pathway
BPTASGO:0002224toll-like receptor signaling pathway
BPIBAGO:0002237response to molecule of bacterial origin
BPTASGO:0002237response to molecule of bacterial origin
BPIDAGO:0002639positive regulation of immunoglobulin production
BPIEAGO:0002755MyD88-dependent toll-like receptor signaling pathway
BPIEAGO:0006954inflammatory response
BPIBAGO:0006955immune response
BPIBAGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0007252I-kappaB phosphorylation
BPIDAGO:0010628positive regulation of gene expression
BPISSGO:0030277maintenance of gastrointestinal epithelium
BPIDAGO:0030890positive regulation of B cell proliferation
BPIDAGO:0032088negative regulation of NF-kappaB transcription factor activity
BPIBAGO:0032640tumor necrosis factor production
BPIDAGO:0032640tumor necrosis factor production
BPISSGO:0032715negative regulation of interleukin-6 production
BPIDAGO:0032717negative regulation of interleukin-8 production
BPIDAGO:0032722positive regulation of chemokine production
BPIDAGO:0032725positive regulation of granulocyte macrophage colony-stimulating factor production
BPISSGO:0032728positive regulation of interferon-beta production
BPISSGO:0032733positive regulation of interleukin-10 production
BPISSGO:0032735positive regulation of interleukin-12 production
BPISSGO:0032741positive regulation of interleukin-18 production
BPIBAGO:0032755positive regulation of interleukin-6 production
BPIDAGO:0032755positive regulation of interleukin-6 production
BPIDAGO:0032757positive regulation of interleukin-8 production
BPISSGO:0032760positive regulation of tumor necrosis factor production
BPIDAGO:0034122negative regulation of toll-like receptor signaling pathway
BPIDAGO:0034123positive regulation of toll-like receptor signaling pathway
BPTASGO:0034162toll-like receptor 9 signaling pathway
BPIDAGO:0034163regulation of toll-like receptor 9 signaling pathway
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPNASGO:0042742defense response to bacterium
BPIDAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0043410positive regulation of MAPK cascade
BPIDAGO:0043507positive regulation of JUN kinase activity
BPIBAGO:0045078positive regulation of interferon-gamma biosynthetic process
BPIDAGO:0045078positive regulation of interferon-gamma biosynthetic process
BPTASGO:0045087innate immune response
BPIDAGO:0045356positive regulation of interferon-alpha biosynthetic process
BPIBAGO:0045359positive regulation of interferon-beta biosynthetic process
BPIDAGO:0045359positive regulation of interferon-beta biosynthetic process
BPIBAGO:0045416positive regulation of interleukin-8 biosynthetic process
BPIDAGO:0045577regulation of B cell differentiation
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPICGO:0046330positive regulation of JNK cascade
BPIEAGO:0050707regulation of cytokine secretion
BPICGO:0050729positive regulation of inflammatory response
BPIMPGO:0050829defense response to Gram-negative bacterium
BPIDAGO:0050871positive regulation of B cell activation
BPIBAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIBAGO:0051607defense response to virus
BPISSGO:0051770positive regulation of nitric-oxide synthase biosynthetic process
BPIDAGO:1901224positive regulation of NIK/NF-kappaB signaling
BPIDAGO:1901895negative regulation of calcium-transporting ATPase activity

Gene expression in normal tissue: TLR9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TLR9

DatabasePathway IDPathway Des.
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP3858Toll-like Receptor Signaling
wikipathwaysWP3877Simplified Depiction of MYD88 Distinct Input-Output Pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05143African trypanosomiasis - Homo sapiens (human)
kegghsa05144Malaria - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
biocartatollpathwaytoll-like receptor pathway
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1679131Trafficking and processing of endosomal TLR
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-975110TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD670ML 2103
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD512nutlin 33
iGMDRD446LY 21832404
iGMDRD286Nsc 6328393
iGMDRD71Sparfosic acid3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TLR9