Summary: This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016].

TNF receptor superfamily member 1AMIM:191190Ensembl:ENSG00000067182HGNC:HGNC:11916PA3660912p13.31

GO terms in TNFRSF1A

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005031tumor necrosis factor-activated receptor activity
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFIBAGO:0043120tumor necrosis factor binding
BPISSGO:0003176aortic valve development
BPISSGO:0003177pulmonary valve development
BPISSGO:0003332negative regulation of extracellular matrix constituent secretion
BPIEAGO:0006693prostaglandin metabolic process
BPISSGO:0006954inflammatory response
BPTASGO:0007249I-kappaB kinase/NF-kappaB signaling
BPTASGO:0008625extrinsic apoptotic signaling pathway via death domain receptors
BPIEAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0010614negative regulation of cardiac muscle hypertrophy
BPTASGO:0010803regulation of tumor necrosis factor-mediated signaling pathway
BPIEAGO:0016032viral process
BPISSGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPIMPGO:0033209tumor necrosis factor-mediated signaling pathway
BPTASGO:0033209tumor necrosis factor-mediated signaling pathway
BPIMPGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPIEAGO:0042742defense response to bacterium
BPIEPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0050728negative regulation of inflammatory response
BPISSGO:0050729positive regulation of inflammatory response
BPIEPGO:0071260cellular response to mechanical stimulus
BPTASGO:0071550death-inducing signaling complex assembly
BPIMPGO:0072659protein localization to plasma membrane
BPISSGO:1902339positive regulation of apoptotic process involved in morphogenesis
BPIMPGO:1903140regulation of establishment of endothelial barrier
BPTASGO:2000304positive regulation of ceramide biosynthetic process
CCIDAGO:0000139Golgi membrane
CCNASGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIDAGO:0005615extracellular space
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0009986cell surface
CCIDAGO:0043235receptor complex
CCIDAGO:0045121membrane raft

Gene expression in normal tissue: TNFRSF1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNFRSF1A

DatabasePathway IDPathway Des.
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2447Amyotrophic lateral sclerosis (ALS)
wikipathwaysWP2513Nanoparticle triggered regulated necrosis
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP384Apoptosis Modulation by HSP70
wikipathwaysWP3850Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling
wikipathwaysWP4063Interleukin-10 signaling
wikipathwaysWP453Inflammatory Response Pathway
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidceramide_pathwayCeramide signaling pathway
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidnfkappabcanonicalpathwayCanonical NF-kappaB pathway
pidtnfpathwayTNF receptor signaling pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
biocartaceramidepathwayceramide signaling pathway
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartakeratinocytepathwaykeratinocyte differentiation
biocartanfkbpathwaynf-kb signaling pathway
biocartasoddpathwaysodd/tnfr1 signaling pathway
biocartastresspathwaytnf/stress related signaling
biocartatnfr1pathwaytnfr1 signaling pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5357786TNFR1-induced proapoptotic signaling
reactomeR-HSA-5357905Regulation of TNFR1 signaling
reactomeR-HSA-5357956TNFR1-induced NFkappaB signaling pathway
reactomeR-HSA-5626978TNFR1-mediated ceramide production
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5669034TNFs bind their physiological receptors
reactomeR-HSA-6783783Interleukin-10 signaling
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-75893TNF signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD679Bistramide A2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNFRSF1A