ARHGDIB


Summary: Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Rho GDP dissociation inhibitor betaMIM:602843Ensembl:ENSG00000111348HGNC:HGNC:679PA2496412p12.3

GO terms in ARHGDIB


Term TypeEvidence TypeGO Term IDGO Des.
MFIMPGO:0003924GTPase activity
MFIBAGO:0005094Rho GDP-dissociation inhibitor activity
MFIDAGO:0005094Rho GDP-dissociation inhibitor activity
MFIEAGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
MFIBAGO:0048365Rac GTPase binding
MFIDAGO:0048365Rac GTPase binding
BPTASGO:0007162negative regulation of cell adhesion
BPIBAGO:0007266Rho protein signal transduction
BPTASGO:0007275multicellular organism development
BPIDAGO:0035023regulation of Rho protein signal transduction
BPIMPGO:0035023regulation of Rho protein signal transduction
BPIEAGO:0043547positive regulation of GTPase activity
BPTASGO:0051056regulation of small GTPase mediated signal transduction
BPIEAGO:0071461cellular response to redox state
BPIDAGO:1901164negative regulation of trophoblast cell migration
BPIMPGO:2000249regulation of actin cytoskeleton reorganization
CCTASGO:0005737cytoplasm
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCTASGO:0005856cytoskeleton
CCIBAGO:0016020membrane
CCIEAGO:0016020membrane
CCTASGO:0031410cytoplasmic vesicle
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: ARHGDIB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARHGDIB


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle
biocartacaspasepathwaycaspase cascade in apoptosis
biocartad4gdipathwayd4gdi signaling pathway
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
netpathPathway_TCRTCR
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidrhoa_reg_pathwayRegulation of RhoA activity
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04962Vasopressin-regulated water reabsorption - Homo sapiens (human)
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP524G13 Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD187BRD98766
iGMDRD494Neopeltolide6
iGMDRD420Leucascandrolide A3
iGMDRD387CHIR-990211
iGMDRD158NSC1415403
iGMDRD451Serdemetan3
iGMDRD356PNU-746541
iGMDRD280CYTOCHALASIN B3
iGMDRD505Pevonedistat3
iGMDRD886Compound 1541A3
iGMDRD61Kinetin riboside1
iGMDRD57Chloropentafluorobenzene3
iGMDRD100Zebularine1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARHGDIB

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